351227-42-4

Basic information

• Product Name: 6-CHLORO-4-IODOPYRIDIN-3-AMINE
• Synonyms: 6-CHLORO-4-IODOPYRIDIN-3-AMINE;(6-Chloro-4-iodopyridin-3-yl)amine;3-Pyridinamine, 6-chloro-4-iodo-
• CAS NO: 351227-42-4
• Molecular Formula: C₅H₄ClIN₂
• Molecular Weight: 254.4561
• Mol File: 351227-42-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 359.374 °C at 760 mmHg
• Flash Point: 171.144 °C
• Appearance: /
• Density: 2.139±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.708
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.60±0.10(Predicted)
• CAS DataBase Reference: 6-CHLORO-4-IODOPYRIDIN-3-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-4-IODOPYRIDIN-3-AMINE(351227-42-4)
• EPA Substance Registry System: 6-CHLORO-4-IODOPYRIDIN-3-AMINE(351227-42-4)

Safety Data

• Hazardous Substances Data: 351227-42-4(Hazardous Substances Data)

Usage

General Description

6-Chloro-4-iodopyridin-3-amine is a chemical compound with the molecular formula C5H4ClIN2. It is a heterocyclic amine containing a pyridine ring with chlorine and iodine substituents. 6-Chloro-4-iodopyridin-3-amine has potential applications in organic synthesis and medicinal chemistry, as it can be used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It may also have biological activity and be used as a research tool in the development of new drugs. The specific properties and uses of 6-Chloro-4-iodopyridin-3-amine may vary depending on its exact chemical structure and purity.

InChI:InChI=1/C5H4ClIN2/c6-5-1-3(7)4(8)2-9-5/h1-2H,8H2

Upstream product

• 400777-00-6 (6-chloro-4-iodopyridin-3-yl)carbamic acid tert-butyl ester 
• 171178-45-3 tert-butyl (6-chloropyridin-3-yl)carbamate 
• 5350-93-6 6-Chloro-pyridin-3-ylamine 

Downstream Products

• 800402-01-1 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid [1-(S)-(tert-butyldimethylsilanyloxymethyl)-2-(S)-hydroxy-2-phenylethyl]amide 
• 800402-02-2 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid [1-(S)-(tert-butyldimethylsilanyloxymethyl)-2-oxo-2-phenylethyl]amide 
• 800401-99-4 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid [2-phenyl-1-(S)-(2-phenyl-[1,3]dioxolan-2-yl)ethyl]amide 
• 800397-99-3 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid[1-(S)-(4-fluorobenzyl)-2-(4-hydroxypiperidin-1-yl)-2-oxoethyl]amide 
• 800398-38-3 (S)-3-[(5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carbonyl)amino]-(R)-2-hydroxy-4-phenylbutyric acid 
• 800398-36-1 2-(S)-[(5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carbonyl)amino]-3-phenylpropionic acid 

Relevant articles and documents

AZAINDOLE DERIVATIVES AS CFTR MODULATORS

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDES

Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.

Azaindole derivatives and their use as therapeutic agents

The present invention relates to compounds of the formula (I): wherein: Het represents a heterocyclic residue selected from: where the dotted line in (b) represents an optional double bond; A completes a fused pyridine ring; and B completes a fused benzene or pyridine ring. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic neuralgia.