342613-14-3Relevant articles and documents
Ferrocenyl Paclitaxel and Docetaxel Derivatives: Impact of an Organometallic Moiety on the Mode of Action of Taxanes
Wieczorek, Anna,B?au?, Andrzej,?al, Aleksandra,Arabshahi, Homayon John,Reynisson, Jóhannes,Hartinger, Christian G.,Rychlik, B?a?ej,Pla?uk, Damian
supporting information, p. 11413 - 11421 (2016/08/03)
A series of ferrocenyl analogues and derivatives of paclitaxel and docetaxel were synthesised and assayed for their antiproliferative/cytotoxic effects, impact on the cell cycle distribution and ability to induce tubulin polymerisation. The replacement of the 3′-N-benzoyl group of paclitaxel with a ferrocenoyl moiety, in particular, led to formation of an analogue that was at least one order of magnitude more potent in terms of antiproliferative activity than the parent compound (IC50values of 0.11 versus 1.11 μm, respectively), but still preserved the classical taxane mode of action, that is, microtubule stabilisation leading to mitotic arrest. Molecular docking studies revealed an unexpected binding pocket in the tubulin structure for the ferrocenoyl group introduced in the paclitaxel backbone.
CABAZITAXEL, RELATED COMPOUNDS AND METHODS OF SYNTHESIS
-
Page/Page column 34, (2013/05/09)
The invention provides new cabazitaxel isoserine ester intermediates and new synthetic methods, and a preparation method for the anti-tumour drugs cabazitaxel, docetaxel and paclitaxel from the new cabazitaxel isoserine intermediates.
Radiosynthesis of [11C]docetaxel
Van Tilburg,Franssen,Van Der Hoeven,Van Der Meij,Elshove,Lammertsma,Windhorst
, p. 763 - 777 (2007/10/03)
Docetaxel (Taxotere) is an accepted chemotherapeutic agent for the treatment of breast cancer and non-small cell lung cancers. A potential means of predicting response is measuring tumor uptake of [11C]docetaxel using Positron Emission Tomograp
