34221-41-5 Usage
Description
4,4'-DIHYDROXY-2-METHOXYCHALCONE is a chalcone derivative characterized by its chemical structure featuring two hydroxyl groups at the 4 and 4' positions, and a methoxy group at the 2 position. It is a naturally occurring compound found in various plants and has been recognized for its potential biological activities.
Uses
Used in Pharmaceutical Industry:
4,4'-DIHYDROXY-2-METHOXYCHALCONE is used as a bioactive compound for its potential therapeutic applications. It has been identified for its various pharmacological properties, which include anti-inflammatory, antioxidant, and antimicrobial activities. These properties make it a promising candidate for the development of new drugs targeting a range of health conditions.
Used in Anticancer Applications:
Similar to Echinatin, 4,4'-DIHYDROXY-2-METHOXYCHALCONE is used as an anticancer agent, inhibiting key enzymes such as DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1. By targeting these enzymes, it can disrupt essential cellular processes in cancer cells, leading to their growth inhibition and eventual death. This makes it a valuable compound in the development of novel anticancer therapies.
Used in Drug Delivery Systems:
To enhance the bioavailability and therapeutic efficacy of 4,4'-DIHYDROXY-2-METHOXYCHALCONE, it can be incorporated into various drug delivery systems. These systems, which may include organic and metallic nanoparticles, can improve the compound's solubility, stability, and targeted delivery to cancer cells, thereby enhancing its overall effectiveness in cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 34221-41-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,2,2 and 1 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 34221-41:
(7*3)+(6*4)+(5*2)+(4*2)+(3*1)+(2*4)+(1*1)=75
75 % 10 = 5
So 34221-41-5 is a valid CAS Registry Number.
InChI:InChI=1/C16H14O4/c1-20-16-10-14(18)8-4-12(16)5-9-15(19)11-2-6-13(17)7-3-11/h2-10,17-18H,1H3/b9-5+
34221-41-5Relevant articles and documents
A new isoflavone and the corresponding isoflavanone of licorice root
Saitoh,Noguchi,Shibata
, p. 144 - 147,145.146 (1978)
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Chalcones, inhibitors for topoisomerase i and cathepsin B and L, as potential anti-cancer agents
Kim, Seok-Ho,Lee, Eunyoung,Baek, Kyung Hye,Kwon, Han Byeol,Woo, Hyunjung,Lee, Eung-Seok,Kwon, Youngjoo,Na, Younghwa
, p. 3320 - 3324 (2013/06/27)
In order to diversify the pharmacological activity of chalcones and extend the scaffold of topoisomerase and cathepsins B and L inhibitors, we have designed and synthesized total 18 chalcone compounds and tested their biological activity. In the topoisome
Synthesis and topoisomerase II inhibitory and cytotoxic activity of oxiranylmethoxy- and thiiranylmethoxy-chalcone derivatives
Na, Younghwa,Nam, Jung-Min
scheme or table, p. 211 - 214 (2011/02/25)
In order to find potential anticancer drug candidate targeting topoisomerases enzyme, we have designed and synthesized oxiranylmethoxy- and thiiranylmethoxy-retrochalcone derivatives and evaluated their pharmacological activity including topoisomerases inhibitory and cytotoxic activity. Of the compounds prepared compound 25 showed comparable or better cytotoxic activity against cancer cell lines tested. Compound 25 inhibited MCF7 (IC50: 0.49 ± 0.21 μM) and HCT15 (IC50: 0.23 ± 0.02 μM) carcinoma cell growth more efficiently than references. In the topoisomerases inhibition test, all the compounds were inactive to topoisomerase I but moderate inhibitors to topoisomerase II enzyme. Especially, compound 25 inhibited topoisomerase II activity with comparable extent to etoposide at 100 μM concentrations. Correlation between cytotoxicity and topoisomerase II inhibitory activity implies that compound 25 can be a possible lead compound for anticancer drug impeding the topoisomerase II function.
