3416-59-9Relevant articles and documents
Novel benzenesulfonamide and 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives as potential selective COX-2 inhibitors
Taher, Ehab S.,Ibrahim, Tarek S.,Fares, Mohamed,AL-Mahmoudy, Amany M.M.,Radwan, Abdullah F.,Orabi, Khaled Y.,El-Sabbagh, Osama I.
, p. 372 - 382 (2019)
Two new series of 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives containing either five membered heterocyclic rings or aryl hydrazones were synthesized and evaluated for their in vitro COX-1/COX-2 inhibitory activity. In vivo anti-inflammatory evalu
In situ Generation and Utilization of CO: An Efficient Route towards N-Substituted Saccharin via Carbonylative Cyclization of 2-Iodosulfonamides
Chavan, Sujit P.,Adithyaraj,Bhanage, Bhalchandra M.
supporting information, p. 2000 - 2003 (2017/09/13)
The present protocol demonstrates the synthesis of N-substituted saccharines via carbonylative cyclization of 2-iodosulfonamides using a Pd(OAc) 2 /Xantphos catalyst system and phenyl formate as a CO source. A variety of saccharin derivatives is synthesized under milder reaction conditions.
Decarbonylative C-C bond-forming reactions of saccharins by nickel catalysis: Homocoupling and cycloaddition
Mi, Pengbing,Liao, Peiqiu,Tu, Tao,Bi, Xihe
supporting information, p. 5332 - 5336 (2015/03/30)
Decarbonylation of saccharins by nickel catalysis enables two kinds of C-C bond-forming reactions; homocoupling of saccharins to form biaryls and cycloaddition with alkynes to form benzosultams. The former represents the first reported nickel-catalyzed decarbonylative C-C homocoupling reaction, whereas the latter constitutes a powerful method to pharmaceutically relevant benzosultams. The reactions proceed with good functional-group tolerance and excellent regioselectivity.