340291-70-5

Basic information

• Product Name: 2-[1-(S)-cyano-(2,2-dimethyl-propyl)amino]-2-(R)-phenyl-acetamide
• Synonyms: 2-[1-(S)-cyano-(2,2-dimethyl-propyl)amino]-2-(R)-phenyl-acetamide
• CAS NO: 340291-70-5
• Molecular Weight: 245.324
• Mol File: 340291-70-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[1-(S)-cyano-(2,2-dimethyl-propyl)amino]-2-(R)-phenyl-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[1-(S)-cyano-(2,2-dimethyl-propyl)amino]-2-(R)-phenyl-acetamide(340291-70-5)
• EPA Substance Registry System: 2-[1-(S)-cyano-(2,2-dimethyl-propyl)amino]-2-(R)-phenyl-acetamide(340291-70-5)

Safety Data

• Hazardous Substances Data: 340291-70-5(Hazardous Substances Data)

Upstream product

• 700-63-0 (R)-phenylglycine amide 
• 143-33-9 sodium cyanide 
• 630-19-3 pivalaldehyde 

Downstream Products

• 62965-57-5 (S)-(+)-2-amino-3,3-dimethylbutanamide 
• 20859-02-3 L-tert-Leucine 
• 340291-72-7 2-[1-(S)-aminocarbonyl-(2,2-dimethyl-propyl)-amino]-2-(R)-phenyl-acetamide 

Relevant articles and documents

Asymmetric strecker synthesis of α-amino acids via a crystallization-induced asymmetric transformation using (R)-phenylglycine amide as chiral auxiliary

Matrix presented Diastereoselective Strecker reactions based on (R)-phenylglycine amide as chiral auxiliary are reported. The Strecker reaction is accompanied by an in situ crystallization-induced asymmetric transformation, whereby one diastereomer selectively precipitates and can be isolated in 76-93% yield and dr > 99/1. The diastereomerically pure α-amino nitrile obtained from pivaldehyde (R1 = t-Bu, R2 = H) was converted in three steps to (S)-tert-leucine in 73% yield and >98% ee.