33973-59-0

Basic information

• Product Name: 2,2,6,6-Tetramethyl-4-piperidone hydrochloride
• Synonyms: 4-Piperidinone, 2,2,6,6-tetramethyl-, hydrochloride;2,2,6,6-Tetramethyl-4-piperidinone·hydrochloride;2,2,6,6-Tetramethyl-4-piperidone hydrochloride,97%;4-Oxo-2,2,6,6-tetramethylpiperidine hydrochloride;2,2,6,6-Tetramethyl-4-azacyclohexanone Hydrochloride Triacetonamine Hydrochloride;2,2,6,6-Tetramethylpiperidin-4-onehydrochloride97%;2,2,6,6-TETRAMETHYL-4-PIPERIDONE HYDROCHLORIDE;2,2,6,6-TETRAMETHYLPIPERIDONE-4 HYDROCHLORIDE
• CAS NO: 33973-59-0
• Molecular Formula: C₉H₁₇NO*ClH
• Molecular Weight: 191.7
• EINECS: 251-769-6
• Product Categories: Heterocyclic Building Blocks;Piperidones;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Building Blocks
• Mol File: 33973-59-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 198 °C (dec.)(lit.)
• Boiling Point: 205.6 °C at 760 mmHg
• Flash Point: 73.2 °C
• Appearance: /
• Density: 0.882g/cm³
• Vapor Pressure: 0.248mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 4154554
• CAS DataBase Reference: 2,2,6,6-Tetramethyl-4-piperidone hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,6,6-Tetramethyl-4-piperidone hydrochloride(33973-59-0)
• EPA Substance Registry System: 2,2,6,6-Tetramethyl-4-piperidone hydrochloride(33973-59-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-24/25
• WGK Germany: 3
• F: 8
• Hazardous Substances Data: 33973-59-0(Hazardous Substances Data)

Usage

Description

2,2,6,6-Tetramethyl-4-piperidone hydrochloride is an organic compound with the chemical formula C9H18ClNO. It is a white crystalline solid that is soluble in water and has a molecular weight of 203.7 g/mol. 2,2,6,6-Tetramethyl-4-piperidone hydrochloride is known for its unique chemical properties and potential applications in various fields.

Uses

Used in Chemical Synthesis:
2,2,6,6-Tetramethyl-4-piperidone hydrochloride is used as a reagent in the miniaturized-SYNthesis and Total Analysis System (πSYNTAS). It is injected into the micromixer using a Rheodyne injection valve to introduce discrete sample pulses, allowing for precise control and monitoring of chemical reactions on a small scale.
This application is particularly useful in the field of chemical research and development, where the ability to perform reactions in a controlled and miniaturized environment can lead to increased efficiency, reduced waste, and the potential for new discoveries. The use of 2,2,6,6-Tetramethyl-4-piperidone hydrochloride in πSYNTAS demonstrates its versatility as a reagent and its potential for contributing to advancements in chemical synthesis techniques.

Purification Methods

Purify the salt by recrystallisation from EtOH/Et2O, MeCN or Me2CO/MeOH. The free base has m 37-39o (after sublimation), b 102-105o/18mm, and the hydrate has m 56-58o (wet Et2O); the hydrobromide has m 203o (from EtOH/Et2O), and the picrate has m 196o (from aqueous EtOH). [Sandris & Ourisson Bull Soc Chim Fr 345 1958, Beilstein 21 H 246, 21 I 273, 21 II 222, 21 III/IV 3278, 21/6 V 538.]

InChI:InChI=1/C9H17NO/c1-8(2)5-7(11)6-9(3,4)10-8/h10H,5-6H2,1-4H3/p+1

Upstream product

• 826-36-8 2,2,6,6-Tetramethyl-4-piperidone 

Downstream Products

• 145640-83-1 4'-(3α-benzyloxychol-24-en)-2',2',6',6'-tetramethylpiperidine-1'-oxyl 
• 45985-24-8 TEMPOL 
• 2403-88-5 4-hydroxy-2,2,6,6-tetramethylpiperidine 
• 858849-89-5 2,2,6,6-tetramethyl-4-hydroxy-4-(1-hydroxy-1-methylethyl)piperidine 
• 55196-74-2 2,2,2',2',6,6,6'6'-octamethyl-4,4'-dihydroxy-4,4'-bipiperidyl 
• 4290-21-5 2,2,4,4-tetramethyl-1,2,3,4-tetrahydro-γ-carboline 
• 45985-26-0 4-oxo-2,2,6,6-tetramethylpiperidin-oxyl 
• 67845-90-3 4-cyano-2,2,6,6-tetramethylpiperidine 

Relevant articles and documents

PROCESSES FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

The disclosure provides processes for preparing a compound of Formula (I).