33390-42-0

Basic information

• Product Name: 1,3,5,8-Tetrahydroxy-2,4-bis(3-methyl-2-butenyl)-9H-xanthen-9-one
• Synonyms: 1,3,5,8-tetrahydroxy-2,4-bis(3-methyl-2-butenyl)-9h-xanthen-9-one;gartanin;1,3,5,8-Tetrahydroxy-2,4-bis(3-methyl-2-butenyl)xanthone;9H-Xanthen-9-one, 1,3,5,8-tetrahydroxy-2,4-bis(3-methyl-2-butenyl)-;Aids098106;Aids-098106;1,3,5,8-Tetrahydroxy-2,4-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one;Gartanin, 98%, from Garcinia mangostana L.
• CAS NO: 33390-42-0
• Molecular Formula: C₂₃H₂₄O₆
• Molecular Weight: 396.43306
• Mol File: 33390-42-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 167℃
• Boiling Point: 644.4 °C at 760 mmHg
• Flash Point: 224.9 °C
• Appearance: /
• Density: 1.326 g/cm³
• Vapor Pressure: 3.33E-17mmHg at 25°C
• Refractive Index: 1.655
• PKA: 7.17±0.20(Predicted)
• CAS DataBase Reference: 1,3,5,8-Tetrahydroxy-2,4-bis(3-methyl-2-butenyl)-9H-xanthen-9-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,5,8-Tetrahydroxy-2,4-bis(3-methyl-2-butenyl)-9H-xanthen-9-one(33390-42-0)
• EPA Substance Registry System: 1,3,5,8-Tetrahydroxy-2,4-bis(3-methyl-2-butenyl)-9H-xanthen-9-one(33390-42-0)

Safety Data

• Hazardous Substances Data: 33390-42-0(Hazardous Substances Data)

Usage

Description

1,3,5,8-Tetrahydroxy-2,4-bis(3-methyl-2-butenyl)-9H-xanthen-9-one is a member of the class of xanthones, characterized by its 9H-xanthen-9-one structure with hydroxy groups at positions 1, 3, 5, and 8, and prenyl groups at positions 2 and 4. 1,3,5,8-Tetrahydroxy-2,4-bis(3-methyl-2-butenyl)-9H-xanthen-9-one is an isoprenylated xanthone that acts as an androgen receptor degradation enhancer and has potential as a neuroprotective agent.

Uses

Used in Pharmaceutical Industry:
1,3,5,8-Tetrahydroxy-2,4-bis(3-methyl-2-butenyl)-9H-xanthen-9-one is used as an anti-proliferative compound for its ability to inhibit cell proliferation, making it a promising candidate for the development of new therapeutic strategies against various diseases, including cancer.
Used in Neuroprotection:
In the field of neuroscience, 1,3,5,8-Tetrahydroxy-2,4-bis(3-methyl-2-butenyl)-9H-xanthen-9-one is used as a potential neuroprotective agent due to its ability to protect neurons from damage and degeneration, which could be beneficial in the treatment of neurodegenerative diseases such as Alzheimer's, Parkinson's, and multiple sclerosis.
Used in Hormone Regulation:
1,3,5,8-Tetrahydroxy-2,4-bis(3-methyl-2-butenyl)-9H-xanthen-9-one is used as an androgen receptor degradation enhancer, which can be applied in the development of treatments for conditions related to androgen receptor dysfunction, such as prostate cancer and other androgen-dependent disorders.

InChI:InChI=1/C23H24O6/c1-11(2)5-7-13-19(26)14(8-6-12(3)4)22-18(20(13)27)21(28)17-15(24)9-10-16(25)23(17)29-22/h5-6,9-10,24-27H,7-8H2,1-4H3

Upstream product

• 108-73-6 3,5-dihydroxyphenol 
• 127716-74-9 1-Hydroxy-3,5,8-trimethoxy-2,4-bis-(3-methyl-but-2-enyl)-xanthen-9-one 
• 114567-42-9 1,3-dihydroxy-5,8-dimethoxyxanthone 
• 60241-74-9 2,3,6-trimethoxybenzoic acid 

Downstream Products

• 33507-91-4 tetra-O-methylgartanin 

Relevant articles and documents

REARRANGEMENT OF 1,3,5,8-TETRAOXYGENATED XANTHONES IN HOT AQUEOUS MORPHOLINE

Aqueous morpholine demethylation of 2-prenyl-1-hydroxy-3,5,8-trimethoxyxanthone leads to a mixture of 1,3,5,8- and 1,3,7,8-tetraoxygenated xanthones.