333366-23-7 Usage
Description
N3-Asp(tBu)-OH (dicyclohexylammonium) salt is a chemical compound that serves as a reagent in the synthesis of acyclic nucleoside phosphonates. These nucleoside phosphonates contain 0-deazahypoxanthine, which is an important component for the inhibition of plasmodial 6-oxopurine phosphoribosyltransferases.
Uses
Used in Pharmaceutical Industry:
N3-Asp(tBu)-OH (dicyclohexylammonium) salt is used as a reagent for the preparation of acyclic nucleoside phosphonates containing 0-deazahypoxanthine. These compounds are crucial in the development of drugs that target and inhibit plasmodial 6-oxopurine phosphoribosyltransferases, which are essential enzymes in the survival and replication of Plasmodium parasites responsible for malaria. By inhibiting these enzymes, the acyclic nucleoside phosphonates can effectively combat malaria and related diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 333366-23-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,3,3,6 and 6 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 333366-23:
(8*3)+(7*3)+(6*3)+(5*3)+(4*6)+(3*6)+(2*2)+(1*3)=127
127 % 10 = 7
So 333366-23-7 is a valid CAS Registry Number.
333366-23-7Relevant articles and documents
BENZODIAZEPINES AS BROMODOMAIN INHIBITORS
-
Page/Page column 86-87, (2017/02/28)
The present invention provides novel benzodiazepine derivatives of Formula I or pharmaceutically acceptable derivatives, polymorphs, salts or prodrugs thereof. Said compounds have potential as bromodomain (BRD) inhibitors.
Solid-phase Staudinger ligation from a novel core-shell-type resin: A tool for facile condensation of small peptide fragments
Kim, Hanyoung,Cho, Jin Ku,Aimoto, Saburo,Lee, Yoon-Sik
, p. 1149 - 1151 (2007/10/03)
Solid-phase Staudinger ligation of small peptides was performed on a novel core-shell-type resin. Solid-phase Staudinger ligation was mediated by synthetic solid-supported phosphinothiol, which was readily prepared by a straightforward synthetic route. This protocol afforded final peptide products in excellent yields and purities and thus could provide the opportunity to facilitate a simple manipulation for condensation of peptide fragments. In particular, the resulting resin could be recycled in a successful manner.