33332-28-4Relevant articles and documents
Preparation technology of 2-bromo-3,5,6-trichloropyrazine
-
Paragraph 0011-0013; 0021-0023; 0030-0032; 0040-0042; 0049, (2018/04/21)
The invention discloses a preparation technology of 2-bromo-3,5,6-trichloropyrazine. The preparation technology comprises the following steps of using 2,6-dichloropyrazine as an initiating raw material, and performing ammoniation, halogenation and Sandmeyer reaction, so as to obtain a target compound, namely 2-bromo-3,5,6-trichloropyrazine. The preparation technology has the advantages that by adopting the synthesis route, the obtaining of raw materials is easy, the cost is low, the operation is simple, the product can be easily separated, the selectivity is high, the yield is higher, the total yield can reach 62.7%, and the preparation technology is favorable for actual application.
PDE9 INHIBITORS WITH IMIDAZO TRIAZINONE BACKBONE AND IMIDAZO PYRAZINONE BACKBONE FOR TREATMENT OF PERIPHERAL DISEASES
-
Page/Page column 23; 24, (2017/02/09)
The present invention relates to PDE9 inhibitors and their use for treatment of benign prostate hyperplasia and sickle cell disease.
PYRROLOTRIAZINES AS POTASSIUM ION CHANNEL INHIBITORS
-
Page/Page column, (2014/09/29)
A compound of formula (I) wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment of arrhythmia, maintaining normal sinus rhythm, IKur-associated disorders, and other disorders mediated by ion channel function.