330976-39-1Relevant articles and documents
Synthesis method of metroprolol succinate ortho-isomer impurities
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Paragraph 0041; 0042; 0043; 0053; 0054; 0055, (2020/03/06)
The invention belongs to the technical field of medicinal chemistry, and particularly relates to a synthesis method of metroprolol succinate ortho-isomer impurities. The synthesis method comprises thesteps: the metroprolol succinate ortho-isomer impurities are prepared by taking salicylaldehyde as a raw material through four steps of reactions, namely the Wittig reaction, the reduction hydrogenation reaction, the substitution reaction and the ring-opening reaction. The synthesis method of the metroprolol succinate ortho-isomer impurities totally includes the four steps of reactions, the raw material is easy to obtain, the total yield is greater than 40%, and contribution is made to strictly control the content of the metroprolol succinate ortho-isomer impurities through an external standard method; and the synthesis method of the metroprolol succinate ortho-isomer impurities is easy to operate, mild in reaction, high in product purity and suitable for drug quality study.
Multidentate phosphite ligands, catalytic compositions containing such ligands, and catalytic prosses utilizing such catalytic compositions
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, (2008/06/13)
Multidentate phosphite ligands are disclosed for use in reactions such as hydrocyanation and isomerization. The catalyst compositions made therefrom and the various catalytic processes which employ such multidentate phosphite ligands are also disclosed. I