330797-85-8

Basic information

• Product Name: (R)-3-(5-bromo-pyridin-3-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester
• Synonyms: (R)-3-(5-bromo-pyridin-3-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS NO: 330797-85-8
• Molecular Weight: 343.22
• Mol File: 330797-85-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-3-(5-bromo-pyridin-3-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-(5-bromo-pyridin-3-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester(330797-85-8)
• EPA Substance Registry System: (R)-3-(5-bromo-pyridin-3-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester(330797-85-8)

Safety Data

• Hazardous Substances Data: 330797-85-8(Hazardous Substances Data)

Upstream product

• 74115-13-2 5-bromopyridine-3-ol 
• 101469-92-5 (S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Synthesis and structure-activity relationship of novel pyridyl ethers for the nicotinic acetylcholine receptor

The preparation of novel pyridyl ethers as ligands for the nicotinic acetylcholine receptor (nAChR) is described. Variations of the ring size of the azacycle and substitution on the pyridine had dramatic effects on receptor binding affinity with IC50S at the α4β2 nAChR ranging from 22 to >10,000 nM. The most potent molecule was (R)-2-chloro-3-(4-cyanophenyl)-5-((3-pyrrolidinyl)oxy)pyridine 27f with an IC50 of 22 nM. (C) 2000 Elsevier Science Ltd. All rights reserved.