33048-55-4

Basic information

• Product Name: 5-METHYL-6-PHENYL-2H-PYRIDAZIN-3-ONE
• Synonyms: AURORA KA-555;5-METHYL-6-PHENYL-2H-PYRIDAZIN-3-ONE;5-methyl-6-phenyl-3(2H)-Pyridazinone;4-methyl-3-phenyl-1H-pyridazin-6-one
• CAS NO: 33048-55-4
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.21
• Mol File: 33048-55-4.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Density: 1.17 g/cm³
• CAS DataBase Reference: 5-METHYL-6-PHENYL-2H-PYRIDAZIN-3-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-6-PHENYL-2H-PYRIDAZIN-3-ONE(33048-55-4)
• EPA Substance Registry System: 5-METHYL-6-PHENYL-2H-PYRIDAZIN-3-ONE(33048-55-4)

Safety Data

• Hazardous Substances Data: 33048-55-4(Hazardous Substances Data)

Upstream product

• 2051-95-8 succinylbenzene 
• 93-55-0 1-phenyl-propan-1-one 
• 298-12-4 Glyoxilic acid 
• 76593-29-8 3-Benzoyl-3-butenoic Acid 
• 64-19-7 acetic acid 
• 67820-83-1 3-chloro-5-methyl-6-phenylpyridazine 
• 23239-13-6 6-phenyl-5-hydroxymethyl-4,5-dihydro-2H-pyridazin-3-one 
• 21034-22-0 β-benzoyl-γ-butyrolactone 

Downstream Products

• 105538-13-4 6-Amino-1-(3-ethoxycarbonyl-propyl)-4-methyl-3-phenyl-pyridazin-1-ium; bromide 
• 105537-65-3 6-Amino-1-(3-carboxy-propyl)-4-methyl-3-phenyl-pyridazin-1-ium; bromide 
• 140149-41-3 (5-Methyl-6-phenyl-pyridazin-3-yl)-hydrazine 
• 105537-96-0 5-Methyl-6-phenyl-pyridazin-3-ylamine 
• 67820-83-1 3-chloro-5-methyl-6-phenylpyridazine 
• 33048-46-3 5-methyl-2-(2-morpholin-4-yl-ethyl)-6-phenyl-2H-pyridazin-3-one 

Relevant articles and documents

Synthesis of regiospecifically polysubstituted pyridazinones

Desymmetrization of pyridazine-3,6-diones by the use of N-benzyl protective groups leads to useful starting materials for building polysubstituted pyridazine libraries in a regioselective manner.

Efficient aromatization of 4,5-dihydro-3(2H)-pyridazinones substituted at 5 position by using anhydrous copper (II) chloride

An efficient conversion of 5-substituted-4,5-dihydro-3(2H)-pyridazinones into their corresponding dehydrogenated derivatives was achieved by treatment with anhydrous copper(II) chloride in acetonitrile.

One-pot preparation of 6-substituted 3(2H)-pyridazinones from ketones

A one-pot process for the preparation of 6-phenyl-3(2H)-pyridazinone from acetophenone and glyoxylic acid has been investigated and shown to have wide utility in the preparation of 6- and 5,6-substituted 3(2H)-pyridazinones. Limitations to the process encountered with 2'-hydroxyacetophenone and with basic hetero-aromatic ketones have been overcome, and the processes described offer the rapid and efficient synthesis of many 6-substituted pyridazinones from readily available ketones.