328945-89-7

Basic information

• Product Name: 2-Acetoxy-1-bromo-4-methoxybenzene
• Synonyms: 2-Acetoxy-1-bromo-4-methoxybenzene
• CAS NO: 328945-89-7
• Molecular Weight: 245.073
• Mol File: 328945-89-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Acetoxy-1-bromo-4-methoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Acetoxy-1-bromo-4-methoxybenzene(328945-89-7)
• EPA Substance Registry System: 2-Acetoxy-1-bromo-4-methoxybenzene(328945-89-7)

Safety Data

• Hazardous Substances Data: 328945-89-7(Hazardous Substances Data)

Upstream product

• 63604-94-4 2-bromo-5-methoxyphenol 
• 108-24-7 acetic anhydride 
• 5451-83-2 acetic acid 3-methoxyphenyl ester 
• 328945-92-2 4-bromo-3-(methoxymethoxy)phenyl 4-methylbenzenesulfonate 
• 171354-06-6 4-bromo-3-(methoxymethoxy)phenol 
• 494773-45-4 4-bromo-3-hydroxy-phenyl 4-methyl-benzenesulfonate 
• 133730-24-2 1-Bromo-4-methoxy-2-(methoxymethoxy)benzene 
• 6626-15-9 4-Bromoresorcinol 
• 75-36-5 acetyl chloride 

Downstream Products

• 63604-94-4 2-bromo-5-methoxyphenol 
• 1194506-26-7 6-(6,7-dimethoxyquinazolin-4-yloxy)-N,2-dimethylbenzofuran-3-carboxamide 
• 854515-52-9 6-hydroxy-2-methyl-benzofuran-3-carboxylic acid 
• 638217-08-0 6-hydroxy-2-methylbenzofuran-3-carboxylic acid methylamide 
• 328945-98-8 Methyl 6-hydroxy-2-[2-hydroxy-4-(tosyloxy)phenyl]benzo[b]furan-3-carboxylate 
• 328945-97-7 Methyl 6-methoxy-2-[2-methoxy-4-(tosyloxy)phenyl]benzo[b]furan-3-carboxylate 
• 328945-88-6 2-Acetoxy-2',4-dimethoxy-4'-(tosyloxy)diphenylacetylene 
• 328945-95-5 2-Hydroxy-2',4-dimethoxy-4'-(tosyloxy)diphenylacetylene 
• 328945-96-6 6-Methoxy-2-[2-methoxy-4-(tosyloxy)phenyl]benzo[b]furan 
• 796089-78-6 coumestrol 
• 479-13-0 coumestrol 
• 57800-41-6 Vignafuran 
• 281191-48-8 2-Acetoxy-1-iodo-4-methoxybenzene 

Relevant articles and documents

Synthetic method of VEGFR inhibitor furoquitinib and benzofuran intermediate thereof

The invention discloses a synthetic method of a VEGFR inhibitor furoquitinib and a benzofuran intermediate thereof. The synthetic method of the VEGFR inhibitor furoquitinib comprises the following steps of S1, halogenation, S2, acylation, S3, coupling, S4

Total syntheses of three natural products, vignafuran, 2-(4-hydroxy-2-methoxyphenyl)-6-methoxybenzofuran-3-carboxylic acid methyl ester, and coumestrol from a common starting material

Vignafuran 2, 2-(4-hydroxy-2-methoxyphenyl)-6-methoxybenzofuran-3-carboxylic acid methyl ester 3, and coumestrol 4 were efficiently synthesized from the same starting material, 4-bromoresorcinol 14a, through the common intermediate, diarylacetylene 7. The key steps of these syntheses were the tetrabutylammonium fluoride (TBAF)-catalyzed benzo[b]furan ring formation for 2 and the carbonylative ring closure methodology catalyzed by a Pd complex for 3 and 4. The Royal Society of Chemistry 2000.