3253-58-5

Basic information

• Product Name: L-Tyrosine, N-acetyl-O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-
• Synonyms: (S)-2-Acetylamino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-propionic acid
• CAS NO: 3253-58-5
• Molecular Formula: C17H14I3NO5
• Molecular Weight: 693.01000
• Mol File: 3253-58-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 136 - 138 °C (aq. methanol)
• CAS DataBase Reference: L-Tyrosine, N-acetyl-O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Tyrosine, N-acetyl-O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-(3253-58-5)
• EPA Substance Registry System: L-Tyrosine, N-acetyl-O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-(3253-58-5)

Safety Data

• Hazardous Substances Data: 3253-58-5(Hazardous Substances Data)

Upstream product

• 6893-02-3 triiodothyronine 
• 64-19-7 acetic acid 

Relevant articles and documents

Preparation method of hapten acetyl iodothyroxine active coupling reagent

The invention discloses a preparation method of a hapten acetyl iodothyroxine active coupling reagent. The preparation method comprises the following steps: preparing acetic acid active ester; subjecting the prepared acetic acid active ester to reacting with iodothyroxine to synthesize an intermediate compound 1; and subjecting the intermediate compound 1 to reacting with N-hydroxysuccinimide and a condensing agent to synthesize the hapten acetyl iodothyroxine active coupling reagent. The preparation method has the advantages of low price and easy availability of raw materials, few synthesis steps, simplicity in operation, convenience in extraction and purification and high yield, provides a brand new solution for synthesizing the hapten acetyl iodothyroxine active coupling reagent, and overcomes problems in synthesis of artificial antigen key raw materials during preparation of monoclonal antibodies from micromolecule haptens and in synthesis of key raw materials in development of kits for clinical detection of thyroid function items.