32449-92-6 Usage
Description
D-(+)-Glucuronic acid γ-lactone, also known as D-Glucurone, Glucourono-γ-lactone, or Glycurone, is a carbohydrate derivative found in plant gums and animal connective tissues. It is a white crystalline substance with a unique crystal structure that has been studied. D-Glucurone is notable for its conversion into L-ascorbic acid, also known as vitamin C, in animals and the human body. Its molecular structure contains two five-membered rings, which contribute to its chemical properties and potential applications.
Uses
Used in Pharmaceutical Industry:
D-Glucurone is used as an intermediate in the synthesis of various pharmaceutical compounds. It serves as a starting reagent in the synthesis of 2,3,4-tris(tert.-butyldimethysilyl) glucuronic acid trichloroethylester, which is required for the preparation of 1-O-acyl glucuronide of the anti-inflammatory drug ML-3000. Additionally, D-Glucurone is utilized in the synthesis of optically active glucopyranoses and long-chain alkyl glucofuranosides, which have potential applications in the development of new drugs and therapeutic agents.
Used in Veterinary Medicine:
D-Glucurone is used as a treatment for canine hepatitis, demonstrating its potential therapeutic value in veterinary medicine. D-Glucurone, specifically D-Glucurono-6,3-lactone, has been studied for its effectiveness against this disease, highlighting its potential as a therapeutic agent for pets and animals.
Purification Methods
Dissolve the lactone or mixture of lactone and acid in H2O and concentrate on a steam bath until crystallisation begins. Cool rapidly to room temperature wih stirring. After 2hours the product is filtered off, washed with cold EtOH and dried to m 174-175o and [] D +19.8o (c 5.2, H2O). The amount of free acid can be obtained by titration of an ice-cold aqueous solution with standard alkali. It can be recrystallised from EtOH, EtOH/H2O or MeOH, and the highest recorded m is 180o. [Stacey J Chem Soc 1529 1939, Mehltretter et al. J Am Chem Soc 73 2424 1951, Beilstein 18 III/IV 3055, 18/5 V 33.]
Check Digit Verification of cas no
The CAS Registry Mumber 32449-92-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,4,4 and 9 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 32449-92:
(7*3)+(6*2)+(5*4)+(4*4)+(3*9)+(2*9)+(1*2)=116
116 % 10 = 6
So 32449-92-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H8O6/c7-1-3-4(12-5(1)9)2(8)6(10)11-3/h1-5,7-9H/t1-,2-,3-,4-,5-/m1/s1
32449-92-6Relevant articles and documents
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Hardegger,Spitz
, p. 2165,2168 (1949)
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Sowden
, p. 4377 (1952)
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Field survey of glycyrrhiza plants in Central Asia (5). Chemical characterization of G. Bucharica Collected in Tajikistan
Hayashi, Hiroaki,Yokoshima, Keiko,Chiba, Ren,Fujii, Isao,Fattokhov, Inoyat,Saidov, Madibron
, p. 534 - 539 (2019/07/22)
One triterpene and five triterpene glycosides, including four new compounds, have been identified in the underground parts of Glycyrrhiza bucharica, which was shown to be closely related to Glycyrrhizin-producing Glycyrrhiza species, G. uralensis, G. glabra and G. inflata, based on their chloroplast rbcL sequences. Two known compounds were identified squasapogenol and macedonoside C. The structures of four new compounds, bucharosides A, B, C, and D, were determined to be 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucuronopyranosyl-(1→2)-β-D-glucuronopyranosyl-22-O-α-L-rhamnopyranosyl squasapogenol, 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucuronopyranosyl-(1→2)-β-D-glucuronopyranosyl-macedonic acid, 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucuronopyranosyl-(1→2)-β-D-glucuronopyranosyl-squasapogenol, and 22-O-α-L-rhamnopyranosyl squasapogenol, respectively. Contents of these triterpene glycosides were less than 0.5% of dry weight, and no main saponin, like glycyrrhizin or macedonoside C found in other Glycyrrhiza species, was found in the underground parts of G. bucharica.
Derivatives of basic polyene macrolides and their preparation
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, (2008/06/13)
The present invention relates to basic polyene macrolide derivatives, characterized in that they comprise a basic polyene macrolide which is N-substituted by a 1-amino-1-deoxyketose group which in turn is substituted or unsubstituted, to a process for their preparation and to their use for obtaining drugs.