32345-19-0

Basic information

• Product Name: (3beta,22E,24xi)-Stigmasta-5,22-dien-3-ol
• CAS NO: 32345-19-0
• Molecular Formula: C₂₉H₄₈O
• Molecular Weight: 412.7
• Mol File: 32345-19-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 501.1°Cat760mmHg
• Flash Point: 219.4°C
• Density: 0.98g/cm³
• CAS DataBase Reference: (3beta,22E,24xi)-Stigmasta-5,22-dien-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (3beta,22E,24xi)-Stigmasta-5,22-dien-3-ol(32345-19-0)
• EPA Substance Registry System: (3beta,22E,24xi)-Stigmasta-5,22-dien-3-ol(32345-19-0)

Safety Data

• Hazardous Substances Data: 32345-19-0(Hazardous Substances Data)

Usage

Description

(3beta,22E,24xi)-Stigmasta-5,22-dien-3-ol is a phytosterol compound found in various plant sources, characterized by a double bond at the 22nd carbon and hydroxyl groups at the 3rd and 24th carbons. It belongs to the class of phytosterols, which are structurally similar to cholesterol and have potential therapeutic properties.

Uses

Used in Pharmaceutical Industry:
(3beta,22E,24xi)-Stigmasta-5,22-dien-3-ol is used as an active pharmaceutical ingredient for its anti-inflammatory and cholesterol-lowering effects. It has potential therapeutic applications in managing inflammation and reducing high cholesterol levels.
Used in Industrial Applications:
(3beta,22E,24xi)-Stigmasta-5,22-dien-3-ol is used as a raw material in the production of various industrial products, such as cosmetics, food supplements, and other health-related products, due to its beneficial properties.

Upstream product

• 139894-63-6 22,23-dihydrostigmasteryl methyl ether 
• 28831-63-2 prosaponin 

Downstream Products

• 122315-97-3 3β-(4-nitro-phenylcarbamoyloxy)-stigmasta-5,22t-diene 
• 122241-67-2 3β-p-tolylcarbamoyloxy-stigmasta-5,22t-diene 
• 53139-42-7 stigmasteryl tosylate 
• 23838-16-6 stearic acid stigmasteryl ester 
• 121212-54-2 3β-(3-phenyl-propionyloxy)-stigmasta-5,22t-diene 
• 80731-53-9 3β-[1]naphthylcarbamoyloxy-stigmasta-5,22t-diene 
• 83-45-4 Stigmastanol 
• 20817-72-5 (22E)-stigmasta-4,22-dien-3-one 
• 64998-20-5 (24S)-stigmasta-5,22E-diene-3β,7β-diol 
• 20817-73-6 24α_FH-stigmastadien-(4.22t)-one-(3)-semicarbazone 
• 107493-31-2 (24R)-5α-stigmastan-3β-ol benzoate 
• 20817-73-6 stigmastadien-(4.22t)-one-(3)-semicarbazone 
• 6160-48-1 3.5-dinitro-benzoic acid-(5α-stigmastanyl-(3β)-ester) 
• 35882-85-0 26,27-dinorergost-5-ene-3β,24-diol 

Relevant articles and documents

NOVEL METHOD FOR SYNTHESIZING 25-OH CHOLESTEROL/CALCIFEDIOL FROM PHYTOSTEROL

The present invention discloses novel method for synthesizing vegan 25-OH cholesterol/Calcifediol from inexpensive crude phytosterol. According to the method, Phytosterols are reacted to form corresponding i-steroid through tosylation and methanolysis. i-steroid on reductive ozonolysis to C-22 alcohol and conversion via C-22 tosylate to C-22 iodide in good yield. Coupling of C-22 tosylate with Grignard reagent of 4-bromo-2-methyl-2-[(trimethylsilyl)oxy] butane followed by deprotection yielded 25-OH cholesterol. In a process variant, nickel mediated conjugate addition of C-22 iodide to an electron deficient alkene ethyl acrylate and treating corresponding ester with methyl magnesium bromide as means of installing the side chain of 25-OH cholesterol in high yield. Further bromination reaction of 25-OH cholesterol diacetate followed by dehydrobromination using TBAF yielded 25-OH 7-dehydrocholesterol. Further photo reaction of 25-OH 7-dehydrocholesterol in to previtamin D3 using high or medium pressure mercury lamp and subsequent thermal reaction of previtamin D3 to 25-OH vitamin D3(Calcifediol) in good yield.

Process for recovery of plant sterols from by-product of vegetable oil refining

The process for recovery of plant sterols and tocopherols from deodorization distillates formed during chemical or physical refining of vegetable oils consists of the following steps: free fatty acids are removed from the deodorization distillate by vacuum distillation or by continuation solvent saponification, after the removal of free fatty acids, the received material is reacted with an aromatic carboxylic acid anhydride at a temperature of 50-150° C., under reduced pressure, after the treatment with anhydride, tocopherols are removed from the mixture, and crystalline free sterols are recovered from the distillation residue containing sterol esters, di- and triglycerides by transesterification.