32086-89-8Relevant articles and documents
Microwave-assisted modified synthesis of C8-analogues of naturally occurring methylxanthines: Synthesis, biological evaluation and their practical applications
Chaudhary, Sandeep,Mathur, Manas,Shyamlal, Bharti Rajesh Kumar,Yadav, Dharmendra K.
, (2020)
An efficient, microwave-assisted, oxidant-interceded, transition-metal-free, cross-dehydrogenative Csp 2-Csp 3 coupling of C8-Caffeine 2/Theobromine 3/theophylline 4 with substituted aliphatic alcohol
Reduction-Triggered Doxorubicin Delivery by Self-Assembled Nanospheres of Lipoylated Caffeine
Chaudhary, Sandeep,Kondaiah, Paturu,Kumar Shyamlal, Bharti Rajesh,Kumar, Krishan,Verma, Rajbala
, (2020)
This study reports a new amphiphilic bioconjugate (CAFF-LA) derived from the lipoylation of a hydroxyethyl derivative of caffeine. In water, CAFF-LA self-assembles into nanospheres with an average size of 155 nm, as evidenced from dynamic light scattering and electron microscopy studies. The nanospheres are stable in serum and could be disintegrated upon exposure to the reducing environment of dithiothreitol (DTT; 10 mM) and glutathione (GSH; 10 mM). These nanospheres easily encapsulate the chemotherapy medication, doxorubicin (DOX), and demonstrate an efficacious transport into doxorubicin-resistant cervical cancer (HeLa) cells, wherein a marked induction in apoptosis and significantly lower IC50 have been observed when compared to that of free drug. The in vitro assessment of cell viability and hemocompatibility present these nanospheres as potentially safe and efficient intracellular reduction stimulus-responsive drug-delivery vehicles.
Photochemical Reactions of Caffeine with Aliphatic Aldehydes
Erndt, Aleksander,Fiedorowicz, Maciej,Kostuch, Andrzej,Para, Andrzej
, p. 1043 - 1046 (2007/10/02)
Photochemical reactions of caffeine with several aliphatic aldehydes are performed.In the reactions with ethanal, propanal and butanal stable 8-acyl-8,9-dihydrocaffeines 2 and 3 together with unreduced 8-acylcaffeines 4 and 8-(α-hydroxy-alkyl)caffeines 6 are produced.Under similar conditions, the reactions of 2-methylpropanal, 2-methylbutanal and 2,2-dimethylbutanal resulted in the formation of the corresponding 8-alkylcaffeines 7. - Key Words: Caffeine / Aldehydes / Photochemistry / Purines