31970-04-4

Basic information

• Product Name: BENZYL 3-PYRROLINE-1-CARBOXYLATE 90
• Synonyms: benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate;N-(Benzyloxycarbonyl)3-pyrroline;2,5-Dihydropyrrole-1-Cbz;N-Cbz-2,5-dihydropyrrole;N-Cbz-3-pyrroline;3-pyrroline-1-benzylcarboxylate;N-Carbobenzoxy-3-pyrroline;benzyl 2H-pyrrole-1(5H)-carboxylate
• CAS NO: 31970-04-4
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.24
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Pyrrolines
• Mol File: 31970-04-4.mol
• Article Data: 43

Chemical Properties

• Boiling Point: 133-137 °C0.6 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Colorless to pale yellow/Liquid
• Density: 1.132 g/mL at 25 °C(lit.)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: n20/D 1.544(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -1.51±0.20(Predicted)
• CAS DataBase Reference: BENZYL 3-PYRROLINE-1-CARBOXYLATE 90(CAS DataBase Reference)
• NIST Chemistry Reference: BENZYL 3-PYRROLINE-1-CARBOXYLATE 90(31970-04-4)
• EPA Substance Registry System: BENZYL 3-PYRROLINE-1-CARBOXYLATE 90(31970-04-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 31970-04-4(Hazardous Substances Data)

Usage

Description

BENZYL 3-PYRROLINE-1-CARBOXYLATE 90 is a heterocyclic building block that serves as a key component in the synthesis of pharmaceutical products, particularly inhibitors. As a colorless liquid, it plays a crucial role in the development of novel compounds with potential therapeutic applications.

Uses

Used in Pharmaceutical Industry:
BENZYL 3-PYRROLINE-1-CARBOXYLATE 90 is used as a synthetic intermediate for the development of various pharmaceutical products, including inhibitors. Its unique structure allows for the creation of new compounds with potential therapeutic benefits.
Used in Synthesis of Pyrrolotriazine:
BENZYL 3-PYRROLINE-1-CARBOXYLATE 90 is used as a key component in the synthesis of a novel series of pyrrolotriazine compounds. These compounds have been found to act as pan-Aurora kinase inhibitors, which are important in the regulation of cell division and have potential applications in the treatment of various diseases, including cancer.

InChI:InChI=1/C12H13NO2/c14-12(13-8-4-5-9-13)15-10-11-6-2-1-3-7-11/h1-7H,8-10H2

Upstream product

• 109-96-6 3-Pyrroline 
• 501-53-1 benzyl chloroformate 
• 100858-33-1 (3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester 
• 98-88-4 benzoyl chloride 
• 75315-63-8 N-(benzyloxycarbonyl)succinimide 
• 6913-92-4 1-benzyl-2,5-dihydro-1H-pyrrole 
• 63468-63-3 2,5-dihydro-1H-pyrrole hydrochloride 
• 95656-88-5 benzyl 3-hydroxypyrrolidine-1-carboxylate 
• 1885-14-9 phenyl chloroformate 
• 25070-76-2 benzyl diallylcarbamate 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 

Downstream Products

• 124391-76-0 -(+)-methanol 
• 122225-42-7 3,4-cis-dihydroxy-pyrrolidine-1-carboxylic acid benzyl ester 
• 100858-32-0 (S)-3-hydroxy-1-pyrrolidinecarboxylic acid phenylmethyl ester 
• 100858-33-1 (3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester 
• 95656-88-5 benzyl 3-hydroxypyrrolidine-1-carboxylate 
• 681424-87-3 (1α,5α,6α)-3-benzyloxycarbonyl-3-azabicyclo[3.1.0]hexane-6-carboxylic acid tert-butyl ester 
• 1061340-05-3 C₂₅H₂₂ClFN₂O₂ 
• 1269755-12-5 (3S,4S)-benzyl 3-fluoro-4-vinylpyrrolidine-1-carboxylate 
• 1269755-19-2 (3R,4S)-benzyl 3-hydroxy-4-vinylpyrrolidine-1-carboxylate 
• 1269755-18-1 (3S,4R)-benzyl 3-hydroxy-4-vinylpyrrolidine-1-carboxylate 
• 1269755-11-4 (3R,4S)-1-(benzyloxycarbonyl)-4-fluoropyrrolidine-3-carboxylic acid 
• 1269755-14-7 (3S,4S)-benzyl 3-(4-methoxybenzoyloxy)-4-vinylpyrrolidine-1-carboxylate 
• 1269755-15-8 (3S,4S)-benzyl 3-hydroxy-4-vinylpyrrolidine-1-carboxylate 
• 1269755-16-9 (3S,4S)-benzyl 3-(tert-butyldiphenylsilyloxy)-4-vinylpyrrolidine-1-carboxylate 

Relevant articles and documents

Completely Recyclable Monomers and Polycarbonate: Approach to Sustainable Polymers

It is of great significance to depolymerize used or waste polymers to recover the starting monomers suitable for repolymerization reactions that reform recycled materials no different from the virgin polymer. Herein, we report a novel recyclable plastic: degradable polycarbonate synthesized by dinuclear chromium-complex-mediated copolymerization of CO2 with 1-benzyloxycarbonyl-3,4-epoxy pyrrolidine, a meso-epoxide. Notably, the novel polycarbonate with more than 99 % carbonate linkages could be recycled back into the epoxide monomer in quantitative yield under mild reaction conditions. Remarkably, the copolymerization/depolymerization processes can be achieved by the ON/OFF reversible temperature switch, and recycled several times without any change in the epoxide monomer and copolymer. These characteristics accord well with the concept of perfectly sustainable polymers.

DEUTERATED HETEROCYCLIC COMPOUNDS AND THEIR USE AS IMAGING AGENTS

The present invention relates to deuterated and optionally detectably labeled compounds of formula (I): R1-A-R2 and formula (V) and salts thereof, wherein Rl, R2, A, and X10-X19 have any of

CELL PROLIFERATION INHIBITORS AND CONJUGATES THEREOF

Disclosed herein are immunoconjugates comprising an inhibitor of Eg5 linked to an antigen binding moiety such as an antibody, useful for treating cell proliferative disorders. Also disclosed are novel inhibitors of Eg5 that can be used either alone or as part of an immunoconjugate to treat cell proliferation disorders. The Eg5 inhibitors include compounds of this formula as described herein: [insert last structure from page 68 here] The invention further provides pharmaceutical compositions comprising these compounds and immunoconjugates, optionally including a therapeutic co-agent, and methods to use these compounds, conjugates and compositions for treating cell proliferation disorders.