312537-30-7

Basic information

• Product Name: [4-(2-chloro-4-nitro-pheny1)-piperazin-1-yl]-[3-(2-chloro-phenyl)-5-methylisoxazol-4-yl]-methanone
• Synonyms: [4-(2-chloro-4-nitro-pheny1)-piperazin-1-yl]-[3-(2-chloro-phenyl)-5-methylisoxazol-4-yl]-methanone
• CAS NO: 312537-30-7
• Molecular Weight: 461.304
• Mol File: 312537-30-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [4-(2-chloro-4-nitro-pheny1)-piperazin-1-yl]-[3-(2-chloro-phenyl)-5-methylisoxazol-4-yl]-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(2-chloro-4-nitro-pheny1)-piperazin-1-yl]-[3-(2-chloro-phenyl)-5-methylisoxazol-4-yl]-methanone(312537-30-7)
• EPA Substance Registry System: [4-(2-chloro-4-nitro-pheny1)-piperazin-1-yl]-[3-(2-chloro-phenyl)-5-methylisoxazol-4-yl]-methanone(312537-30-7)

Safety Data

• Hazardous Substances Data: 312537-30-7(Hazardous Substances Data)

Upstream product

• 114878-60-3 1-(2-chloro-4-nitro-phenyl)piperazine 
• 23598-72-3 3-(2-chlorophenyl)-5-methyl-4-isoxazolecarboxylic acid 

Downstream Products

• 1370421-10-5 (4-(4-amino-2-chlorophenyl)piperazin-1-yl)(3-(2-chlorophenyl)-5-methylisoxazol-4-yl)methanone 
• 1370421-09-2 (4-(4-azido-2-chlorophenyl)piperazin-1-yl)(3-(2-chlorophenyl)-5-methylisoxazol-4-yl)methanone 

Relevant articles and documents

NOVEL PIPERAZINE ANALOGS WITH SUBSTITUTED HETEROARYL GROUPS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS

A compound of the following Formula (I) is set forth, including pharmaceutically acceptable salts thereof: wherein Het is a 5 or 6-membered heterocycle with -N, -O, or -S adjacent to the -Ar substituent or adjacent to the point of attachment for the -Ar substituent; Ar is aryl or heteroaryl; R is -CH3, -CH2F, -CHF2 or -CH=CH2; V is -H, -CH3 or =0; W is -NO2, -CI, -Br, -CH2OH, or -CN; X is -CI, -Br, -F, -CH3, -OCH3, or -CN; Y is -CH or -N; and Z is -CH or -N. This compound is useful in compositions for the prevention and treatment of influenza virus.

ANTIVIRAL COMPOUNDS AND METHODS OF MAKING AND USING THEREOF

Compounds which exhibit antiviral activity, particularly against influenza virus, and methods of making and using thereof are described herein. In one embodiment, the compounds are heterocyclic amides containing piperazine and isozazole rings and optionally substituted with one or more substituents. The compounds can be formulated with one or more pharmaceutically acceptable excipients to form compositions suitable for enteral or parenteral administration. The compounds are preferably used to treat or prevent Influenza A infections, such as H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, and H10N7.