3106-85-2 Usage
Description
N-ACETYL-ASP-GLU, also known as N-acetyl aspartyl-glutamic acid or spaglumic acid, is a dipeptide composed of N-acetyl-L-aspartic acid and L-glutamic acid joined by a peptide linkage. It is a neuropeptide and a neurotransmitter that is abundant in the mammalian nervous system. Its chemical properties include a white powder form. N-ACETYL-ASP-GLU is a marker of neuronal integrity and has been used in the detection of therapeutic values of antidrepressant treatments.
Uses
1. Used in Neurological Applications:
N-ACETYL-ASP-GLU is used as a marker of neuronal integrity for the detection of therapeutic values of antidrepressant treatments. It helps in assessing the effectiveness of treatments targeting neurological disorders and conditions.
2. Used in N-acetylated α-linked acidic dipeptidase (NAALADase) Assay and Affinity Experiments:
N-ACETYL-ASP-GLU is used as a substrate in NAALADase assay and affinity experiments, which are crucial for understanding the role of this enzyme in various biological processes and its potential as a therapeutic target.
3. Used in Pharmaceutical Research:
As a neurotransmitter, N-ACETYL-ASP-GLU is involved in the functioning of the mammalian nervous system. It is used in pharmaceutical research to explore its potential as a therapeutic agent for neurological disorders and conditions, particularly those related to neuronal integrity and function.
4. Used in Research on NMDA Receptors and mGluR3:
N-ACETYL-ASP-GLU is used in research to determine its role as a selective agonist of mGluR3, both in vitro and in vivo. While its activation of NMDA receptors remains uncertain, understanding its interaction with these receptors can provide insights into its potential therapeutic applications.
Biochem/physiol Actions
Endogenous neurotransmitter localized to neurons with high affinity for metabotropic glutamate receptors, mGluR3. It is an antagonist at NMDA receptors. Catabolized by carboxypeptidase II, which is expressed on astrocyte membranes, to N-acetylaspartate and glutamate.
Check Digit Verification of cas no
The CAS Registry Mumber 3106-85-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,1,0 and 6 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 3106-85:
(6*3)+(5*1)+(4*0)+(3*6)+(2*8)+(1*5)=62
62 % 10 = 2
So 3106-85-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1
3106-85-2Relevant articles and documents
PEPTIDES WITH CYTOPROTECTIVE ACTIVITY
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Paragraph 0025; 0026, (2016/03/05)
This invention is related to medicine and concerns peptides with cytoprotective activity selected from a group that includes Ac-Asp-Glu-OH, H-Asp-Glu-OCH3, H-Asp-Glu-NH - CH2-CH3, H-Val-Asp-Glu-OH, H-Leu-Asp- Glu-OH and H-
