30918-54-8 Usage
Description
Polyinosinic acid, also known as Poly(I), is a homopolymer of inosine that serves as a crucial component in the formation of double-stranded homopolymers when combined with polycytidylic acid (poly(C)). It is recognized as a TLR3 (Toll-like receptor 3) agonist, known for its ability to induce interferon production. Poly(I) exhibits hypochromicity of ≥40% at 248 nm and an extinction coefficient of 5000 M^-1cm^-1 at 260 nm, pH 7.0. It is utilized as an agent for the generation of stable, mature dendritic cells (DC) and acts as an immunostimulant. Chemically, it is a white or off-white powder, soluble in water, and insoluble in organic solvents such as ethanol and acetaminophen.
Uses
1. Used in Biomedical Applications:
Polyinosinic acid is used as an oligolysines for nucleic acid binding and other biomedical applications, playing a significant role in the study and development of various medical treatments.
2. Used in Immune Response:
Polyinosinic acid, when combined with polycytidylic acid (poly(C)) to form (Poly(I).Poly(C)), is used as a model RNA to study cell signaling at the level of TLR3. This double-stranded RNA is recognized by TLR3, which is a major effector of the immune response against viral pathogens.
3. Used in Generation of Dendritic Cells:
Polyinosinic acid is used as an agent for the generation of stable, mature dendritic cells (DC), which are essential for initiating and regulating immune responses.
4. Used as an Immunostimulant:
Acting as an immunostimulant, polyinosinic acid enhances the body's immune response, making it a valuable tool in the development of vaccines and therapies targeting various diseases.
5. Used in Drug Delivery Systems:
Although not explicitly mentioned in the provided materials, polyinosinic acid's role in the formation of double-stranded homopolymers and its interaction with TLR3 could potentially be utilized in the development of novel drug delivery systems, similar to how gallotannin is used in overcoming limitations and enhancing applications in cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 30918-54-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,9,1 and 8 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 30918-54:
(7*3)+(6*0)+(5*9)+(4*1)+(3*8)+(2*5)+(1*4)=108
108 % 10 = 8
So 30918-54-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H13N4O8P/c15-5-3(1-21-23(18,19)20)22-7(6(5)16)9-13-4-8(14-9)11-2-12-10(4)17/h2-3,5-7,15-16H,1H2,(H2,18,19,20)(H2,11,12,13,14,17)/t3-,5-,6-,7-/m1/s1
