30748-29-9 Usage
Description
Feprazone is an anti-inflammatory agent that is primarily used in the management of inflammatory or degenerative joint diseases. It is known by various brand names such as Bentudor, Brotazona, Cocresol, Da 2370, Danfenona, Feniprenazone, Fepramole, Golaman, Impremial, Metrazone, Naoven, Nazona, Nessazona, Prenakes, Rangozona, Represil, Solielin, Tbrien, Vapesin, Zontal, and Zoontal.
Uses
Used in Pharmaceutical Industry:
Feprazone is used as an anti-inflammatory agent for the management of inflammatory or degenerative joint diseases. It helps in reducing pain, swelling, and stiffness associated with these conditions, thereby improving the patient's quality of life and mobility.
In addition to its primary use, Feprazone may also be utilized in other applications within the pharmaceutical industry, such as a component in the development of new drugs or formulations targeting inflammation and related conditions.
Originator
Zepelin,De Angeli,Italy,1972
Manufacturing Process
43.8 g (0.237 mol) of hydrazobenzene are added to a solution of sodium
ethylate obtained by dissolving 6.55 g (0.285 mol) of sodium in 125 ml of
anhydrous ethanol. 59.6 g (0.2612 mol) of diethyl 3-methyl-2-butenyl malonate are then added, with stirring, at the reflux temperature.The reaction mixture is refluxed for 1 hour, then the solvent is slowly distilled
off, the distillation being completed in vacuo. The solid residue so obtained is
dissolved in 400 ml of water and washed with ether. The solution is acidified
with 10% HCl and the 1,2-diphenyl-3,5-dioxo-4-(3'-methyl-2'-butenyl)-
pyrazolidine which separates is purified by crystallization from ethanol (MP
155°C to 156°C).
Therapeutic Function
Antiinflammatory
World Health Organization (WHO)
Feprazone, a pyrazolone derivative with antiinflammatory,
analgesic and antipyretic activity, was introduced in 1978 for the treatment of
rheumatic disorders. As it is structurally related to phenylbutazone it is subjected
to rigorously restricted indications by some national regulatory authorities. See
WHO comment for phenylbutazone. WHO has been informed that to date feprazone
is only available in some 7 countries.
Check Digit Verification of cas no
The CAS Registry Mumber 30748-29-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,7,4 and 8 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 30748-29:
(7*3)+(6*0)+(5*7)+(4*4)+(3*8)+(2*2)+(1*9)=109
109 % 10 = 9
So 30748-29-9 is a valid CAS Registry Number.
InChI:InChI=1/C20H20N2O2/c1-15(2)13-14-18-19(23)21(16-9-5-3-6-10-16)22(20(18)24)17-11-7-4-8-12-17/h3-13,18H,14H2,1-2H3
