300801-52-9

Basic information

• Product Name: TG003
• Synonyms: Cdc2-Like Kinase Inhibitor, TG003;TG003/TG-003;2-Propanone,1-(3-ethyl-5-Methoxy-2(3H)-benzothiazolylidene)-;(1Z)-1-(3-Ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one;1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone;(Z)-1-(3-ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one;1-(3-Ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one
• CAS NO: 300801-52-9
• Molecular Formula: C13H15NO2S
• Molecular Weight: 249.333
• Product Categories: Inhibitors
• Mol File: 300801-52-9.mol
• Article Data: 0

Chemical Properties

• Melting Point: 132-132.5 °C
• Boiling Point: 386°C at 760 mmHg
• Flash Point: 187.2°C
• Appearance: pale yellow/solid
• Density: 1.237g/cm³
• Vapor Pressure: 3.65E-06mmHg at 25°C
• Refractive Index: 1.638
• Storage Temp.: 2-8°C
• Solubility: DMSO: 33 mg/mL
• PKA: -1.76±0.20(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: TG003(CAS DataBase Reference)
• NIST Chemistry Reference: TG003(300801-52-9)
• EPA Substance Registry System: TG003(300801-52-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 300801-52-9(Hazardous Substances Data)

Usage

Description

TG003 is a novel benzothiazole compound that acts as a potent and specific ATP-competitive inhibitor of Cdc2-like kinase (Clk) family members, particularly Clk1/Sty and Clk4. It is known for its ability to modify the regulation of alternative splicing modulated by phosphorylation of SR proteins in vitro and has demonstrated potential in rescuing developmental defects in Xenopus caused by an overabundance of Clk activity.

Uses

Used in Cell Culture and In Vitro Kinase Assays:
TG003 is utilized in PAC1 cell culture and in vitro kinase assays, providing a valuable tool for researchers to study the effects and mechanisms of Clk inhibition.
Used in Research and Development of Therapeutic Treatments:
As a potent CDC-2 kinase inhibitor, TG003 is used in the research and identification of signaling pathways that could lead to the development of possible therapeutic treatments targeting Clk-related processes.
Used in the Study of Alternative Splicing Regulation:
TG003 is employed in the study of alternative splicing regulation, as it modifies the phosphorylation of SR proteins, which play a crucial role in the process. This application aids in understanding the underlying mechanisms and potential therapeutic applications related to splicing regulation.
Used in Pharmaceutical Industry:
TG003 is used as a Cdc2-Like Kinase Inhibitor in the pharmaceutical industry for the development of drugs targeting Clk family members, which are involved in various cellular processes and diseases.
Used in Developmental Biology Research:
In developmental biology research, TG003 is used to study the effects of excessive Clk activity on embryonic development in Xenopus and to explore potential methods for rescuing the induced defects.

Biochem/physiol Actions

TG003, a CLK (cdc2-like kinase) family inhibitor is used as a drug for duchenne muscular dystrophy.

InChI:InChI=1/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7-