2946-89-6

Basic information

• Product Name: 1-NITROGUANYL-3,5-DIMETHYL-PYRAZOLE
• Synonyms: 1-NITROGUANYL-3,5-DIMETHYL-PYRAZOLE;3,5-Dimethyl-N1-nitro-1H-pyrazole-1-carboxamidine;3,5-Dimethyl-N'-nitro-1H-pyrazole-1-carboxamidine;N'-Nitro-3,5-dimethyl-1H-pyrazole-1-carboxamidine
• CAS NO: 2946-89-6
• Molecular Formula: C₆H₉N₅O₂
• Molecular Weight: 183.17
• Mol File: 2946-89-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-NITROGUANYL-3,5-DIMETHYL-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-NITROGUANYL-3,5-DIMETHYL-PYRAZOLE(2946-89-6)
• EPA Substance Registry System: 1-NITROGUANYL-3,5-DIMETHYL-PYRAZOLE(2946-89-6)

Safety Data

• Hazardous Substances Data: 2946-89-6(Hazardous Substances Data)

Usage

Type of compound

Organic compound

Contains groups

Nitroguanyl group, 3,5-dimethylpyrazole group

Uses

Synthesis of pharmaceuticals and agrochemicals

Potential applications

Vasodilator, antioxidant, reactive intermediate in organic synthesis

Interest to researchers and chemists

Unique structure and potential applications in various fields

Upstream product

• 18264-75-0 1-amino-2-nitroguanidine 
• 123-54-6 acetylacetone 
• 18264-75-0 3-amino-1-nitroguanidine 

Downstream Products

• 955082-12-9 N-(2-fluoro-4-{4-[2-(phenoxymethyl)-1H-imidazol-4-yl]phenoxy}phenyl)-N-nitroguanidine 
• 23441-10-3 N-Benzyloxycarbonyl-N^G-nitroagmatin 
• 158474-92-1 N⁴-(4-Azidobenzyloxycarbonyl)-N¹,N⁸-bis(nitroguanidino)spermidine 
• 78314-78-0 C₁₆H₂₃N₅O₇S 
• 78314-71-3 C₂₁H₂₈N₆O₆S 
• 14531-55-6 3,5-dimethyl-4-nitro-1H-pyrazole 
• 100524-26-3 N-anilino-N'-nitro-guanidine 
• 5461-83-6 N-nitro-N'-phenyl-guanidine 

Relevant articles and documents

Structure and synthesis of 3,5-dimethyl-N-nitro-1H-pyrazole-1-carboxamidine

A new approach to the synthesis of 3,5-dimethyl-N-nitro-1H-pyrazole-1-carboxamidine was developed based on condensing 1-amino-2-nitroguanidine with pentane-2,4-dione under alkaline catalysis. The known method of its preparation in the presence of acetic acid was improved. The structure of 3,5-dimethyl-N-nitro-1H-pyrazole-1-carboxamidine was characterized by NMR, IR spectroscopy and X-ray diffraction analysis.

Optimisation of the synthesis of guanidines from amines via nitroguanidines using 3,5-dimethyl-N-nitro-1H-pyrazole-1-carboxamidine

The synthesis of the useful reagent for the preparation of guanidines, 3,5-dimethyl-N-nitro-1-pyrazole-1-carboxamidine (DMNPC), has been optimised. A detailed protocol for using this reagent for the preparation in pure form of a range of guanidines via nitroguanidines is described. A comparison has been made regarding efficiency between DMNPC and the guanidinylating reagents N,N′-bis-Boc-1-pyrazole-1-carboxamidine (2) and N,N′-bis-Boc- N′-triflylguanidine (3).

Enzyme Inhibiting substance

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