28321-11-1

Basic information

• Product Name: 1-chloro-2-(2,2-difluorovinyl)benzene
• Synonyms: 1-chloro-2-(2,2-difluorovinyl)benzene
• CAS NO: 28321-11-1
• Molecular Weight: 174.578
• Mol File: 28321-11-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-chloro-2-(2,2-difluorovinyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-2-(2,2-difluorovinyl)benzene(28321-11-1)
• EPA Substance Registry System: 1-chloro-2-(2,2-difluorovinyl)benzene(28321-11-1)

Safety Data

• Hazardous Substances Data: 28321-11-1(Hazardous Substances Data)

Upstream product

• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 89-98-5 2-chloro-benzaldehyde 
• 1895-39-2 sodium chlorodifluoroacetate 

Downstream Products

• 2856-63-5 2-Chlorophenylacetonitrile 
• 84966-80-3 2-(2-chlorophenyl)-N,N-dimethylacetamide 
• 28321-15-5 N,N-Diethyl-2-chlorphenylethinylamin 

Relevant articles and documents

Direct Approach to N-Substituted-2-Fluoroindoles by Sequential Construction of C-N Bonds from gem-Difluorostyrenes

A mild and efficient synthesis of N-substituted-2-fluoroindole derivatives was achieved via Buchwald-Hartwig couplings and a sequential, base-promoted intramolecular nucleophilic reaction-β-fluorine elimination. By employing easily obtained gem-difluorostyrenes and primary arylamines, the scope, advantages, and limitations of this reaction were well investigated. Furthermore, this strategy distinguishes itself by high modularity, operational simplicity, and a wide substrate scope, giving rise to a broad array of 2-fluoroindole derivatives in moderate to excellent yields.

Organocatalytic Nucleophilic Substitution Reaction of gem-Difluoroalkenes with Ketene Silyl Acetals

An organocatalytic nucleophilic substitution reaction of gem-difluoroalkenes with ketene silyl acetals was developed. Phosphazene P4-tBu effectively catalyzed the reaction under mild conditions to provide monofluoroalkenes possessing an alkoxycarbonylmethyl group in high yields with high Z selectivities.

Visible light photocatalytic decarboxylative monofluoroalkenylation of α-amino acids with: Gem -difluoroalkenes

α-Amino acids are among the most common biologically active molecules in nature, and their functionalization has attracted much attention. In this communication, a novel, efficient and general visible-light photocatalytic decarboxylative monofluoroalkenylation of N-protected α-amino acids with gem-difluoroalkenes is reported, affording the corresponding α-amino monofluoroalkenes which might find applications in medical chemistry and materials science. The reaction proceeded at room temperature with high efficiency and tolerance of various functional groups.