273-53-0 Usage
Description
Benzoxazole is an organic compound characterized by a benzene ring fused to a 1,3-oxazole ring across positions 4 and 5. It is a colorless to yellow crystalline solid with a low melting point.
Uses
Used in Pharmaceutical Industry:
Benzoxazole is used as a building block for the synthesis of various pharmaceutical compounds due to its unique chemical structure and properties. It plays a crucial role in the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
Benzoxazole is used as an intermediate in the synthesis of various organic compounds, including dyes, pigments, and other specialty chemicals. Its versatile structure allows for a wide range of reactions and modifications, making it a valuable component in the chemical industry.
Used in Material Science:
Benzoxazole is used in the development of advanced materials, such as polymers and coatings, due to its stability and ability to form strong intermolecular interactions. Its incorporation into these materials can enhance their properties, such as thermal stability, mechanical strength, and resistance to degradation.
Used in Electronics Industry:
Benzoxazole and its derivatives have potential applications in the electronics industry, particularly in the development of organic light-emitting diodes (OLEDs) and other optoelectronic devices. Their unique electronic properties make them promising candidates for improving the performance and efficiency of these devices.
Used in Agrochemical Industry:
Benzoxazole compounds are also used in the agrochemical industry as active ingredients in pesticides and herbicides. Their ability to interact with specific biological targets makes them effective in controlling pests and unwanted plant growth, contributing to increased crop yields and improved agricultural practices.
Safety Profile
Poison by intraperitoneal andintravenous routes. Moderately toxic by ingestion. Whenheated to decomposition it emits toxic fumes such asNOx.
Check Digit Verification of cas no
The CAS Registry Mumber 273-53-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,7 and 3 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 273-53:
(5*2)+(4*7)+(3*3)+(2*5)+(1*3)=60
60 % 10 = 0
So 273-53-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H5NO/c1-2-4-7-6(3-1)8-5-9-7/h1-5H
273-53-0Relevant articles and documents
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Kozlov,N.S.,Kiselev,B.I.
, (1966)
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Photocyclization of o-Nitrophenyl Alkyl Ethers
Oguchi, Shoshichi,Torizuka, Hiroshi
, p. 2425 (1980)
o-Nitrophenyl alkyl ethers 1a, 1b, and 1c undergo photocyclization to give benzoxazoles 2a, 2b, and 2c, respectively.
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Grellmann,Taner
, p. 375,376 (1974)
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Synthetic Applications of a New Magnetic Mesoporous Nanocomposite Catalyst Fe3O4@MCM-41@NH-SO3H
Pourhasan-Kisomi, Reyhaneh,Shirini, Farhad,Golshekan, Mostafa
, p. 166 - 175 (2021/04/09)
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Synthesis of isocyanides by reacting primary amines with difluorocarbene
Si, Yi-Xin,Zhu, Peng-Fei,Zhang, Song-Lin
supporting information, p. 9086 - 9090 (2020/11/30)
A general, convenient, and friendly route for preparing a versatile building block of isocyanides from primary amines is developed. Difluorocarbene, generated in situ from decarboxylation of chlorodifluoroacetate, reacts efficiently with primary amines to produce isocyanides. Various primary amines are well tolerated, including aryl, heteroaryl, benzyl, and alkyl amines, as well as amine residues in amino acids and peptides. Late-stage functionalization of biologically active amines is demonstrated, showing its practical capacity in drug design and peptide modification.
Visible Light-Induced Copper-Catalyzed C—H Arylation of Benzoxazoles?
Ma, Xiaodong,Zhang, Guozhu
supporting information, p. 1299 - 1303 (2020/08/05)
A general method for visible light-induced copper-catalyzed arylation of sp2 C—H bonds of azoles has been developed. The method employs aryl halide as the coupling partner, lithium alkoxide as base. A variety of azoles including benzooxazole and benzothiazole can be arylated. Furthermore, electron-poor heterocycles such as thiophene possessing one electron-withdrawing group can also be arylated.