2687-94-7 Usage
Description
N-Octyl pyrrolidone (NOP), also known as 1-Octyl-2-pyrrolidone, is a colorless or slightly yellow clear liquid that serves as a highly efficient and selective solvent. It is recognized for its ability to enhance the transport of steroidal permeants across hairless mouse skin through a parallel pathway skin model, making it a valuable permeation enhancer in the pharmaceutical industry.
Uses
Used in Chemical Synthesis:
N-Octyl pyrrolidone is used as a solvent in chemical synthesis reactions for its high efficiency and selectivity, contributing to the production of various organic compounds and materials.
Used in Organic Raw Material Recovery:
NOP is utilized as a solvent in the recovery of organic raw materials, playing a crucial role in the purification and separation processes within the industry.
Used in Lubricating Oil Refining:
In the lubricating oil industry, N-Octyl pyrrolidone is employed as a refining solvent, aiding in the improvement of oil quality and performance.
Used in Polymer and Polymerization Reactions:
NOP serves as a solvent for polymers and polymerization reactions, facilitating the production of various polymeric materials with specific properties and applications.
Used in Pharmaceutical Industry:
As a permeation enhancer, N-Octyl pyrrolidone is used in the pharmaceutical industry to improve the transport of steroidal permeants across hairless mouse skin, potentially leading to advancements in drug delivery and absorption.
Synthesis
N-Octyl pyrrolidone was synthesized by 2-pyrrolidone and tetrabutylammonium bromide stirred with adding n-octane chloride for 10 h at 90 °C.
Synthesis Reference(s)
The Journal of Organic Chemistry, 57, p. 3328, 1992 DOI: 10.1021/jo00038a019
Synthesis Reference(s)
The Journal of Organic Chemistry, 59, p. 6378, 1994 DOI: 10.1021/jo00100a046
Flammability and Explosibility
Nonflammable
Safety Profile
Moderately toxic by ingestion. Asevere skin and eye irritant. A corrosive. Combustibleliquid. When heated to decomposition it emits toxic fumesof NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 2687-94-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,6,8 and 7 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2687-94:
(6*2)+(5*6)+(4*8)+(3*7)+(2*9)+(1*4)=117
117 % 10 = 7
So 2687-94-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H23NO/c1-2-3-4-5-6-7-10-13-11-8-9-12(13)14/h2-11H2,1H3
2687-94-7Relevant articles and documents
Extension of the Eschweiler-Clarke procedure to the N-alkylation of amides
Fache, Fabienne,Jacquot, Laurent,Lemaire, Marc
, p. 3313 - 3314 (1994)
The selective N-alkylation of amides (cyclic or acyclic) under hydrogen is reported using aldehydes or ketones as alkylating agents and Pd/C/Na2SO4 as catalyst. Good isolated yields are obtained (81% to 98%).
Process for the preparation of N-substituted lactams
-
, (2008/06/13)
The invention relates to a process for the preparation of N-substituted lactams by reaction of a lactam, which is unsubstituted on the nitrogen, with an organic halide in the presence of at least one solid-liquid phase transfer catalyst, such as a quaternary ammonium salt, and of at least one solid inorganic base, such as an alkali metal hydroxide, and in the absence of solvent. By this process, N-substituted lactams are obtained with good yields and high purity. The absence of solvent makes possible a considerable gain in productivity and an improvement in safety and in regard for the environment.
N-allyl-lactams as crystallization inhibitors
-
, (2008/06/13)
Crystallization of active material in spraying of an aqueous solution of certain specified fungicides is retarded by incorporation therein of an N-alkyl-lactam of the formula STR1 in which R represents alkyl having 6 to 18 carbon atoms and n represents the numbers 3, 4 or 5.