26820-94-0

Basic information

• Product Name: methyl 3-(4,5-diphenyloxazol-2-yl)propanoate
• Synonyms: methyl 3-(4,5-diphenyloxazol-2-yl)propanoate
• CAS NO: 26820-94-0
• Molecular Weight: 307.349
• Mol File: 26820-94-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: methyl 3-(4,5-diphenyloxazol-2-yl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(4,5-diphenyloxazol-2-yl)propanoate(26820-94-0)
• EPA Substance Registry System: methyl 3-(4,5-diphenyloxazol-2-yl)propanoate(26820-94-0)

Safety Data

• Hazardous Substances Data: 26820-94-0(Hazardous Substances Data)

Upstream product

• 4107-62-4 3-cyano-propionic acid methyl ester 
• 501-65-5 diphenyl acetylene 
• 365-01-5 2,2-difluoro-2-phenylacetophenone 
• 591-50-4 iodobenzene 
• 591-51-5 phenyllithium 
• 2248-46-6 ethyl 2,2-difluoro-2-phenylacetate 
• 1494-20-8 2,2-difluoro-1,2-diphenylethan-1-ol 
• 451-40-1 phenyl benzyl ketone 
• 52944-79-3 3,3'-Dimethoxycarbonylpropanoic anhydride 
• 64-19-7 acetic acid 

Downstream Products

• 21256-18-8 3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid 
• 108056-25-3 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanol 
• 34015-83-3 3-(4,5-diphenyloxazol-2-yl)propanehydrazide 

Relevant articles and documents

PROCESS FOR FORMING A CARBON-CARBON BOND

A process for forming a carbon-carbon bond to couple an aryl or heteroaryl group of a first compound with an aryl or heteroaryl group of a second compound, the process comprising reacting the first compound with the second compound in the presence of a catalytically effective amount of a neutral or cationic ruthenium(II) catalyst of formula (I):

Metal-free syntheses of oxazoles and their analogues based on λ3-iodane-mediated cycloisomerization/functionalization reactions or [2+2+1] cycloaddition type reactions

As a metal-free construction of oxazoles and furans concomitant with the introduction of oxygen functional groups or fluorine atoms into the side chains, we have developed λ3-iodane-mediated cycloisomerization/functionalization reactions of propargyl compounds. In these reactions, aryl- λ3-iodane ArI(X)Y works not only as a donor of heteroatomic functional groups but also as an activator of carbon-carbon triple bonds. Therefore, this methodology is not required any transition metal catalysts, which are frequently used in previous methods. Furthermore, this methodology can be extended to λ3-iodane-mediated [2+2+1] cycloaddition type reactions of alkynes, nitriles and heteroatoms for metal-free formation of oxazoles and imidazoles.

Metal-free [2 + 2 + 1] annulation of alkynes, nitriles, and oxygen atoms: Iodine(III)-mediated synthesis of highly substituted oxazoles

The metal-free [2 + 2 + 1] annulation of alkynes, nitriles, and O-atoms for the regioselective assembly of 2,4-disubstituted and 2,4,5-trisubstituted oxazole compounds has been achieved by the use of PhIO with TfOH or Tf 2NH. The present reaction could be applied to a facile synthesis of an anti-inflammatory drug.