26750-81-2 Usage
Description
Alibendol is a white solid that is an amide analog of Eugenol. It is known for its antispasmodic, choleretic, and cholekinetic properties, making it a versatile compound with potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
Alibendol is used as an antispasmodic agent for treating muscle spasms and related conditions. Its ability to relax smooth muscles helps alleviate pain and discomfort associated with spasms.
Alibendol is also used as a choleretic agent for promoting bile flow and secretion in the liver. This helps improve digestion and absorption of fats and fat-soluble vitamins, as well as supporting the body's detoxification processes.
Furthermore, Alibendol serves as a cholekinetic agent, which enhances the movement of bile through the bile ducts. This can be beneficial in treating conditions such as cholestasis and biliary dyskinesia, where bile flow is impaired.
Originator
Cebera ,Bouchara ,France ,1981
Manufacturing Process
36 g of ethyl ester of 2-hydroxy-3-methoxy-5-allyl-benzoic acid [obtained by
the process described by Pearl, et al., J. Amer. Chem. Soc., Vol. 71, 1067-
1068 (1949)] and 61 g of ethanolamine were admixed and left to stand for 1
hour at ambient temperature after which it was heated for 1 hour at 120°C.
The mixture was extracted with chloroform and the organic phases were
washed with half diluted hydrochloric acid, then with water, and the
chloroform evaporated off. The residue, after recrystallization from benzene,
was a 78% yield of 2-hydroxy-3-methoxy-5-allyl-N-(β-hydroxyethyl)-
benzamide having a melting point of 95°C. The product appeared in the form
of colorless crystals which were insoluble in water and soluble in dilute sodium
hydroxide.
Therapeutic Function
Choleretic, Spasmolytic
Check Digit Verification of cas no
The CAS Registry Mumber 26750-81-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,7,5 and 0 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 26750-81:
(7*2)+(6*6)+(5*7)+(4*5)+(3*0)+(2*8)+(1*1)=122
122 % 10 = 2
So 26750-81-2 is a valid CAS Registry Number.
InChI:InChI=1/C13H17NO4/c1-3-4-9-7-10(13(17)14-5-6-15)12(16)11(8-9)18-2/h3,7-8,15-16H,1,4-6H2,2H3,(H,14,17)
26750-81-2Relevant articles and documents
Choleretic drug alibendol preparation method
-
Paragraph 0017; 0019-0020; 0022, (2019/06/30)
The invention belongs to the field of drug synthesis, and provides an alibendol preparation method, which comprises: selecting 2-hydroxy-3-methoxybenzaldehyde as a raw material, selecting an efficientoxidative esterification catalyst, carrying out one-step oxidative esterification to obtain methyl 2-hydroxy-3-methoxybenzoate, carrying out a reaction on the methyl 2-hydroxy-3-methoxybenzoate and allyl bromide under the action of an alkali to generate methyl 2-allyloxy-3-methoxybenzoate, carrying out a para Claisen rearrangement reaction on the methyl 2-allyloxy-3-methoxybenzoate at a high temperature to obtain methyl 2-hydroxy-3-methoxy-5-allylbenzoate, and carrying out an aminolysis reaction in ethanolamine to generate alibendol. Compared with the traditional synthetic process, the new process of the present invention has characteristics of simple synthesis steps, convenient post-treatment and good product quality, and is suitable for industrial production.