2666-53-7Relevant articles and documents
Synthesis method of beraprost sodium intermediate
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Paragraph 0038-0039; 0041-0042; 0044-0045; 0047-0048; 0056, (2020/12/14)
The invention relates to a synthesis method of a beraprost sodium intermediate I. Cyclopentene and N-bromosuccinimide (NBS) are subjected to a free radical reaction to obtain dibromocyclopentene, anda safer solvent is used for replacing solvents such as carbon tetrachloride and benzene; during preparation of sodium tribromophenolate, sodium hydroxide and other alkalis are used for replacing sodium hydride; 3, 5-bis (2, 4, 6-tribromophenoxy) cyclopentene is directly prepared from generated dibromocyclopentene and 2, 4, 6-tribromophenol sodium through interaction by a'one-pot boiling 'method. The improved reaction conditions are milder, the environment is more friendly, and industrial production is facilitated.
Free Radical Combination Reactions Involving Phenoxyl Radicals
Jonsson, M.,Lind, J.,Reitberger, T.,Eriksen, T. E.,Merenyi, G.
, p. 8229 - 8233 (2007/10/02)
The rates of phenoxyl radical reactions with the superoxide anion radical, O2.-, a peroxyl radical, HOC(CH3)2CH2OO., and an alkyl radical, HOC(CH3)2CH2., in aqueous solution have been measured for 15 different phenoxyl radicals by means of pulse radiolysis.In addition, the one-electron reduction potentials of 10 phenoxyl radicals have been determined.The fraction of electron transfer in the reaction of phenoxyl radicals with O2.- was determined by analysis of γ-irradiated samples.The experimental data can be accommodated by the Marcus theory for electron transfer, with the reorganization energy λ0 = 155 kJ/mol for the reaction between O2.- and phenoxyl radicals.