265651-18-1

Basic information

• Product Name: N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate
• Synonyms: 2-SUCCINIMIDO-1,1,3,3-TETRAMETHYLURONIM HEXAFLUOROPHOSPHATE;2-SUCCINIMIDO-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE;HSTU;O-(N-Succinimidyl)-1,1,3,3-tetramethyluronium hexafluorophosphate;O-(N-SUCCINIMIDYL)-N,N,N',N'-TETRA-;O-(N-Succinimidyl)-N,N,N',N'-tetramethyluroniumhe;o-(n-succinimidyl)-n,n,n',n'-tetra-methyluroniumpf6;HSTU O-(N-SUCCINIMIDYL)-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE
• CAS NO: 265651-18-1
• Molecular Formula: C9H16F6N3O3P
• Molecular Weight: 359.21
• Product Categories: Coupling Reagent
• Mol File: 265651-18-1.mol
• Article Data: 0

Chemical Properties

• Melting Point: 218-221°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: White to off-white/Powder or Crystalline Powder
• Density: g/cm³
• Storage Temp.: Store at 0°C
• Solubility: Soluble in acetonitrile 0.5 g/mL.
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate(CAS DataBase Reference)
• NIST Chemistry Reference: N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate(265651-18-1)
• EPA Substance Registry System: N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate(265651-18-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-60-37
• WGK Germany: 3
• Hazardous Substances Data: 265651-18-1(Hazardous Substances Data)

Usage

Description

N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate, also known as a coupling reagent, is a white to off-white crystalline powder. It is widely used in the synthesis of various compounds, including peptides, amides, and biomolecules for imaging purposes. Its chemical properties make it a versatile and efficient reagent in the field of biochemistry and molecular biology.

Uses

Used in Peptide Synthesis:
N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate is used as a coupling reagent for peptide synthesis and the formation of other amides. It is particularly effective in aqueous solutions, providing excellent yields and facilitating the formation of desired peptide products.
Used in Magnetic Resonance Imaging (MRI):
In the medical imaging industry, N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate is used as a reactant for the synthesis of liposomal contrast agents. These agents enhance the visibility of internal structures during MRI scans, improving diagnostic accuracy.
Used in Protein Labeling:
N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate is used as a reactant for the synthesis of protein labeling molecules. These molecules are essential for tracking and identifying specific proteins within biological systems, aiding in research and understanding of protein functions.
Used in Fluorescence Imaging:
In the field of fluorescence imaging, N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate is used as a reactant for the synthesis of thiol-reactive Cy5 derivatives. These derivatives are valuable for labeling and visualizing biomolecules in various research applications.
Used in Positron Emission Tomography (PET) Imaging:
N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate can be used to prepare N-succinimidyl 4-[18F]fluorobenzoate ([18F]-SFB), a prosthetic group for the fluorination of biomolecules for PET imaging. This application is crucial in the detection and monitoring of various diseases, including cancer, through advanced imaging techniques.