2651-15-2

Basic information

• Product Name: N-[BIS(METHYLTHIO)METHYLENE]-P-TOLUENESULFONAMIDE
• Synonyms: N-[BIS(METHYLTHIO)METHYLENE]-N-TOSYLAMINE;N-[BIS(METHYLTHIO)METHYLENE]-P-TOLUENESULFONAMIDE;Bismethylthiomethylenetoluenesulfonamide;N-(bis(methylthio)methylene)-P-toluene-sulfonamid;N-(4-Methylphenylsulfonyl)imidodithiocarbonic acid dimethyl ester;N-[bis(methylsulfanyl)methylidene]-4-methylbenzenesulfonamide;N-[bis(methylsulfanyl)methylidene]-4-methyl-benzenesulfonamide;N-[bis(methylthio)methylene]-4-methyl-benzenesulfonamide
• CAS NO: 2651-15-2
• Molecular Formula: C₁₀H₁₃NO₂S₃
• Molecular Weight: 275.41
• Product Categories: Sulfur Compounds (for Synthesis);Synthetic Organic Chemistry
• Mol File: 2651-15-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 109-111 °C(lit.)
• Boiling Point: 419°Cat760mmHg
• Flash Point: 207.2°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 7.64E-07mmHg at 25°C
• Refractive Index: 1.598
• PKA: -6.63±0.50(Predicted)
• CAS DataBase Reference: N-[BIS(METHYLTHIO)METHYLENE]-P-TOLUENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-[BIS(METHYLTHIO)METHYLENE]-P-TOLUENESULFONAMIDE(2651-15-2)
• EPA Substance Registry System: N-[BIS(METHYLTHIO)METHYLENE]-P-TOLUENESULFONAMIDE(2651-15-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 2651-15-2(Hazardous Substances Data)

Usage

General Description

N-[bis(methylthio)methylene]-p-toluenesulfonamide is an organic compound used in the production of bioactive compounds and pharmaceuticals. It is a sulfonamide derivative with potential anticancer and antiparasitic properties. This chemical is used as a building block in the synthesis of various biologically active molecules due to its ability to inhibit enzyme activity and possess potential anti-inflammatory effects. Additionally, it has shown potential for use in drug development and research in the field of medicinal chemistry due to its diverse pharmacological activities.

InChI:InChI=1/C10H13NO2S3/c1-8-4-6-9(7-5-8)16(12,13)11-10(14-2)15-3/h4-7H,1-3H3

Upstream product

• 5706-65-0 dipotassium p-tolylsulfonyl dithiocarbamate 
• 77-78-1 dimethyl sulfate 
• 75-15-0 carbon disulfide 
• 70-55-3 toluene-4-sulfonamide 
• 74-88-4 methyl iodide 

Downstream Products

• 77153-09-4 S-methyl-N-<2-(acetylamino)ethyl>-N'-tosylisothiourea 
• 134577-10-9 N-(5-Amino-[1,3,4]thiadiazol-2-yl)-4-methyl-benzenesulfonamide 
• 4073-72-7 3,4,5-triphenyl-1,2,4-triazole 
• 20979-72-0 N-(p-toluenesulfonyl)-N',N',S-trimethylisothiourea 
• 137777-78-7 N-p-toluenesulfonyl-N-methyl-N'-trimethylsilylmethyl-S-methylisothiourea 
• 137777-95-8 4,5-dihydro-3-methyl-5-phenyl-2-(p-toluenesulfonyl)imino-1,3-oxazole 
• 137777-99-2 3-methyl-4,5-dihydro-5,5-diphenyl-2-p-toluenesulfonylimino-1,3-oxazole 
• 135082-03-0 N-<(4-methylphenyl)sulfonyl>-2-nitroacetamide 
• 132622-70-9 (4R)-1-(tert-butoxycarbonyl)-4-<<<(p-toluenesulfonyl)imino>aminomethyl>amino>-L-proline 
• 132622-79-8 (4S)-1-(tert-butoxycarbonyl)-4-<<<(p-toluenesulfonyl)imino>aminomethyl>amino>-D-proline 
• 132622-67-4 (4S)-1-(tert-butoxycarbonyl)-4-<<<(p-toluenesulfonyl)imino>aminomethyl>amino>-L-proline 
• 132622-87-8 (4R)-1-(tert-butoxycarbonyl)-4-<<<<(p-toluenesulfonyl)imino>aminomethyl>amino>methyl>-D-proline 
• 132622-82-3 (4S)-1-(tert-butoxycarbonyl)-4-<<<<(p-toluenesulfonyl)imino>aminomethyl>amino>methyl>-D-proline 
• 132622-73-2 (4S)-1-(tert-butoxycarbonyl)-4-<<<<(p-toluenesulfonyl)imino>aminomethyl>amino>methyl>-L-proline 

Relevant articles and documents

Synthesis of Cyclic Guanidines Bearing N-Arylsulfonyl and N-Cyano Protecting Groups via Pd-Catalyzed Alkene Carboamination Reactions

Palladium-catalyzed carboamination reactions of N-allylguanidines bearing cleavable N-cyano or N-arylsulfonyl protecting groups are described. The reactions afford cyclic guanidine products in good yield, and transformations of substrates bearing internal alkenes proceed with high diastereoselectivity. Deuterium labeling studies indicate these transformations proceed via anti-aminopalladation pathways.

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PYRIDYL GUANIDINE ANTI-ULCER AGENTS

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