263717-53-9 Usage
Description
Propyl pyrazole triol (PPT), also known as 3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole, is a potent and specific agonist for the estrogen receptor α (ERα). ERα, a member of the nuclear receptor superfamily, is located on human chromosome 6q25.1 and is found in both nuclear and extranuclear sites in principal and inhibitory neurons. PPT plays a significant role in various biological processes due to its interaction with ERα.
Uses
Used in Pharmaceutical Industry:
Propyl pyrazole triol is used as a pharmaceutical agent for targeting the estrogen receptor α (ERα). Its application is based on its potent and specific agonist activity, which allows it to modulate the functions of ERα in various cellular processes.
Used in Research Applications:
In the field of research, Propyl pyrazole triol is used as a research tool for studying the role of ERα in cellular processes and its potential involvement in various diseases. Its specific agonist activity makes it a valuable compound for investigating the mechanisms of ERα signaling and its implications in health and disease.
Used in Drug Development:
Propyl pyrazole triol is utilized in drug development as a lead compound for designing new therapeutic agents targeting ERα. Its potent agonist activity and specificity for ERα make it a promising starting point for the development of novel drugs with potential applications in treating conditions related to ERα dysregulation.
Used in Hormone Replacement Therapy:
In the context of hormone replacement therapy, Propyl pyrazole triol may be used as an ERα agonist to help alleviate symptoms associated with estrogen deficiency, such as those experienced during menopause. Its specific targeting of ERα could potentially offer a more targeted approach to hormone replacement therapy, reducing the risk of side effects and complications.
Biological Activity
Potent, subtype-selective estrogen receptor agonist (EC 50 ~ 200 pM); displays 410-fold selectivity for ER α over ER β . Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo .
Biochem/physiol Actions
Estrogen receptor α (ERα) is involved in immune and inflammatory responses. Aberrations in ESR1 results in Mayer-Rokitansky-Kuster-Hauser syndrome that is associated with the congenital absence of the uterus and the upper two-thirds of the vagina.
Check Digit Verification of cas no
The CAS Registry Mumber 263717-53-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,3,7,1 and 7 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 263717-53:
(8*2)+(7*6)+(6*3)+(5*7)+(4*1)+(3*7)+(2*5)+(1*3)=149
149 % 10 = 9
So 263717-53-9 is a valid CAS Registry Number.
