2624-48-8 Usage
General Description
Nicotine bi-L-(+)-tartrate is a salt form of nicotine, a highly addictive stimulant drug found in tobacco and responsible for the addictive qualities of cigarette smoking. This chemical is commonly used in smoking cessation products such as nicotine replacement therapy (NRT) to help individuals quit smoking by reducing cravings and withdrawal symptoms. It works by binding to nicotine receptors in the brain, mimicking the effects of nicotine found in cigarettes. The bi-L-(+)-tartrate form of nicotine is water-soluble, making it suitable for use in various pharmaceutical and medical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 2624-48-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,6,2 and 4 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2624-48:
(6*2)+(5*6)+(4*2)+(3*4)+(2*4)+(1*8)=78
78 % 10 = 8
So 2624-48-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N2.2C4H6O6/c1-12-7-3-5-10(12)9-4-2-6-11-8-9;2*5-1(3(7)8)2(6)4(9)10/h2,4,6,8,10H,3,5,7H2,1H3;2*1-2,5-6H,(H,7,8)(H,9,10)/t;2*1-,2-/m.11/s1
2624-48-8Relevant articles and documents
Disposition kinetics of nicotine and cotinine enantiomers in rabbits and beagle dogs
Jacob III,Benowitz,Copeland,Risner,Cone
, p. 396 - 400 (2007/10/02)
The disposition kinetics of nicotine and cotinine enantiomers was determined in rabbits. The clearance of (R)-nicotine was similar to that of (S)-nicotine, but clearance of (R)-cotinine was twice that of (S)-cotinine. Fractional conversions of both enantiomers of nicotine to cotinine were ~50%. These results suggest that in rabbits the biotransformation pathways of cotinine, but not nicotine, are influenced by stereochemistry. The disposition kinetics of nicotine enantiomers in beagle dogs was also studied. In dogs, the clearance of (R)-nicotine was slightly greater than the clearance of (S)-nicotine. Methods for the synthesis of (R)-nicotine and (R)-cotinine of high enantiomeric purity and a gas chromatographic method for determination of nicotine enantiomeric purity are described.
