261952-04-9 Usage
General Description
3-Methyl-5-(trifluoromethyl)benzonitrile, also known by its CAS number 768-33-2, is a chemical compound with a molecular formula of C9H6F3N. It is a colorless to pale yellow liquid with a faint odor, and is non-soluble in water. 3-METHYL-5-(TRIFLUOROMETHYL)BENZONITRILE is commonly used in organic synthesis and pharmaceutical manufacturing processes as a building block for various chemicals and pharmaceuticals. It is also used as an intermediate in the production of agrochemicals and dyes. Additionally, it can act as a ligand in coordination chemistry and can participate in various chemical reactions such as nitration and reduction. It is important to handle this compound with care as it is a potential irritant to the skin, eyes, and respiratory system.
Check Digit Verification of cas no
The CAS Registry Mumber 261952-04-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,1,9,5 and 2 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 261952-04:
(8*2)+(7*6)+(6*1)+(5*9)+(4*5)+(3*2)+(2*0)+(1*4)=139
139 % 10 = 9
So 261952-04-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H6F3N/c1-6-2-7(5-13)4-8(3-6)9(10,11)12/h2-4H,1H3
261952-04-9Relevant articles and documents
Trifluoromethylation of Arylsilanes with [(phen)CuCF3]
Morstein, Johannes,Hou, Haiyun,Cheng, Chen,Hartwig, John F.
supporting information, p. 8054 - 8057 (2016/09/13)
A method for the trifluoromethylation of arylsilanes is reported. The reaction proceeds with [(phen)CuCF3] as the CF3source under mild, oxidative conditions with high functional-group compatibility. This transformation complements prior trifluoromethylation of arenes in several ways. Most important, this method converts arylsilanes formed by the silylation of aryl C?H bonds to trifluoromethylarenes, thereby allowing the conversion of arenes to trifluoromethylarenes. The unique capabilities of the reported method are demonstrated by the conversion of a C?H bond into a C?CF3bond in active pharmaceutical ingredients which do not undergo this overall transformation by alternative functionalization processes, including a combination of borylation and trifluoromethylation.
