26027-38-3 Usage
Description
POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER, also known as Nonoxynol, is a non-ionic surfactant with a general formula of C9H19C6H4(OCH2CH2)nOH. Each nonoxynol is characterized by the number (n) of ethylene oxide units in the chain. It is a clear, colorless, or light yellow, viscous liquid. Nonoxynols are commonly used in various applications due to their surfactant properties, and they can act as irritants and sensitizers.
Uses
Used in Industrial Applications:
POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER is used as a sensitizing agent in industrial hand cleansers and crack-indicating fluids used in the metal industry.
Used in Topical Antiseptics:
POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER is used as a preservative in topical antiseptics, helping to maintain the cleanliness and safety of the products.
Used in Contraceptives:
POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER is used as a spermatocide and contraceptive, preventing the fertilization of eggs by immobilizing or killing sperm cells.
Used in UV-B Photosensitization:
Nonoxynol-10, a specific type of POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER, is used as a UV-B photosensitizer, which can be useful in various applications such as photopolymerization or photodynamic therapy.
Used in Household Products:
Nonoxynol-12 (nonylphenol ethoxylate), a variant of POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER, has been reported to cause contact dermatitis in individuals who use household products containing it, such as polishes.
Used in Detergents and Liquid Soaps:
POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER is used as a surfactant in detergents and liquid soaps, enhancing their cleaning and emulsifying properties.
Used in Emulsifiers for Creams:
POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER is used as an emulsifier in creams, helping to maintain a stable mixture of oil and water components.
Used in Fabric Softeners:
POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER is used in fabric softeners to provide a soft and smooth texture to fabrics.
Used in Photographic Paper Additives:
POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER is used as an additive in photographic paper, improving the quality and performance of the final product.
Used in Hair Dyes:
POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER is used in hair dyes, contributing to the even distribution of color and improving the overall appearance of the dye.
Used in Lubricating Oils:
POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER is used in lubricating oils, enhancing their performance and reducing friction between moving parts.
Used in Anti-infective Agents:
POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER is used in anti-infective agents, helping to prevent the growth of harmful microorganisms.
Originator
Ortho-Delfen ,Cilag,France,1971
Manufacturing Process
220 parts of isononylphenol prepared by condensation of phenol with an olefin mixture obtained by polymerization of propylene and containing essentially isononylenes are caused to react with 0.5 part of caustic alkali powder. The whole is heated to about 130°C to 135°C and the water formed is removed under reduced pressure, while stirring. Thereupon, ethylene oxide is introduced into the melt, while well stirring, during which operation care must be taken, that the temperature of the reaction mass is maintained between 180°C and 200°C. When about 300 parts of ethylene oxide are taken up, the reaction is interrupted. A water-soluble oil is obtained.
Therapeutic Function
Spermatocide (vaginal)
Flammability and Explosibility
Notclassified
Contact allergens
Their general formula is C9H19C6H4(OCH2CH2)nOH.
Each nonoxynol is characterized by the number (n) of
ethylene oxide units repeated in the chain; for example,
nonoxynol-9, nonoxynol-14. They are present in
detergents, liquid soaps, emulsifiers for creams, fabric
softeners, photographic paper additives, hair dyes,
lubricating oils, spermicides, and antiinfective agents.
They are irritants and sensitizers. Nonoxynol-6 was
reported as a sensitizing agent in an industrial hand
cleanser and in a crack-indicating fluid in the metal
industry. Nonoxynol-9 is the most commonly used, as
a preservative in topical antiseptics or in spermicides,
acting as a iodophor in PVP-iodine solutions.
Nonoxynol-10 was reported as a UVB-photosensitizer.
Nonoxynol-12 caused contact dermatitis in a domestic
cleaner who used a polish containing it.
Safety Profile
Poison by
intraperitoneal route. Experimental
reproductive effects. Mutation data
reported. An active ingredient in
contraceptive jelhes, foams, and creams.
Combustible when exposed to heat or
flames. When heated to decomposition it
emits acrid smoke and irritating fumes. See
also ALCOHOLS.
Check Digit Verification of cas no
The CAS Registry Mumber 26027-38-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,0,2 and 7 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 26027-38:
(7*2)+(6*6)+(5*0)+(4*2)+(3*7)+(2*3)+(1*8)=93
93 % 10 = 3
So 26027-38-3 is a valid CAS Registry Number.
InChI:InChI=1/C19H32O3/c1-2-3-4-5-6-7-8-9-18-10-12-19(13-11-18)22-17-16-21-15-14-20/h10-13,20H,2-9,14-17H2,1H3
