25972-30-9Relevant articles and documents
Chitosan grafted butein: A metal-free transducer for electrochemical genosensing of exosomal CD24
Babu, Kannadasan Anand,Balasubramanian, Subramanian,Krishnan, Vinoth,Kumar, Shanmugam Senthil,Pandey, Gaurav R.,Paramasivam, Selvaraj,Pazhani, Gururaja Perumal,Ravichandiran, Velayutham,Veerapandian, Murugan
, (2021)
Metal-free cost-efficient biocompatible molecules are beneficial for opto-electrochemical bioassays. Herein, chitosan (CS) conjugated butein is prepared via graft polymerization. Structural integrity between radical active sites of CS and its probable conjugation routes with reactive OH group of butein during grafting were comprehensively studied using optical absorbance/emission property, NMR, FT-IR and XPS analysis. Fluorescence emission of CS-conjugated butein (CSB) was studied in dried flaky state as well as in drop casted form. Cyclic voltammetric study of CSB modified glassy carbon electrode exhibits 2e?/2H+ transfer reaction in phosphate buffered saline electrolyte following a surface-confined process with a correlation coefficient of 0.99. Unlike pristine butein, CSB modified electrode display a highly reversible redox behavior under various pH ranging from 4 to 9. For the proof-of-concept CSB-modified flexible screen printed electrodes were processed for electrochemical biosensing of exosomal CD24 specific nucleic acid at an ultralow sample concentration, promising for ovarian cancer diagnosis.
Analogues of xanthones——Chalcones and bis-chalcones as α-glucosidase inhibitors and anti-diabetes candidates
Cai, Chao-Yun,Rao, Li,Rao, Yong,Guo, Jin-Xuan,Xiao, Zhi-Zun,Cao, Jing-Yu,Huang, Zhi-Shu,Wang, Bo
, p. 51 - 59 (2017/03/01)
Two series of compounds (chalcones and bis-chalcones) were designed, synthesized, and evaluated as α-glucosidase inhibitors (AGIs) with 1-deoxynojirimycin as positive control in vitro. Most of the compounds with two or four hydroxyl groups showed better inhibitory activities than 1-deoxynojirimycin towards α-glucosidase with noncompetitive mechanism. Moreover, most of the hydroxy bis-chalcones exhibit good α-glucosidase inhibitory activities in enzyme test. Inspiringly, bis-chalcones 2g (at 1 μM concentration) has stronger effect than 1-deoxynojirimycin on reducing the glucose level in HepG-2 cells (human liver cancer cell line).
Enantioselective biomimetic total syntheses of kuwanons i and J and brosimones A and B
Han, Jianguang,Li, Xia,Guan, Yong,Zhao, Wenjun,Wulff, William D.,Lei, Xiaoguang
, p. 9257 - 9261,5 (2014/11/07)
The first enantioselective total syntheses of prenylflavonoid Diels-Alder natural products (-)-kuwanonI, (+)-kuwanonJ, (-)-brosimoneA, and (-)-brosimoneB have been accomplished from a common intermediate based on a concise synthetic strategy. Key elements of the synthesis include a biosynthesis-inspired asymmetric Diels-Alder cycloaddition mediated by a chiral ligand/boron Lewis acid, as well as a process involving regioselective Schenck ene reaction, reduction, and dehydration to realize a biomimetic dehydrogenation for generation of the required diene precursor. Furthermore, a remarkable tandem inter-/intramolecular asymmetric Diels-Alder cycloaddition process was applied for the synthesis of (-)-brosimoneA. Four in a row: The first enantioselective total syntheses of the prenylflavonoid natural products (-)-kuwanonI, (+)-kuwanonJ, (-)-brosimoneA, and (-)-brosimoneB have been accomplished based on a concise synthetic strategy. Key elements of the synthesis include a biosynthesis-inspired asymmetric Diels-Alder cycloaddition mediated by a chiral ligand/boron Lewis acid, as well as a process involving regioselective Schenck ene reaction, reduction, and dehydration.
