259529-54-9Relevant articles and documents
Diastereoselective Copper-Mediated Conjugate Addition of Functionalized Magnesiates for the Preparation of Bisaryl Nrf2 Activators
Glogowski, Michal P.,Matthews, Jay M.,Lawhorn, Brian G.,Minbiole, Kevin P. C.
, p. 3120 - 3137 (2021/03/01)
A two-step metal-halogen exchange and diastereoselective copper-mediated Michael addition onto a complex α,β-unsaturated system has been developed and applied toward the synthesis of bisaryl Nrf2 activators. Optimization of metal-halogen exchange using (n
Synthetic studies of cyclic peptides stephanotic acid methyl ester, celogentin C, and moroidin
Li, Lei,Hu, Weimin,Jia, Yanxing
, p. 7753 - 7762 (2014/12/10)
An account of the total synthesis of stephanotic acid methyl ester and celogentin C is presented. The present synthesis features a tandem asymmetric Michael addition/bromination sequence for the synthesis of leucine-tryptophan moiety, and an oxidative coupling reaction to form the tryptophan-imidazole linkage. Moreover, the total synthesis of moroidin had also been studied, and three different synthetic strategies for the construction of the right-hand ring of moroidin were studied.
Diastereoselective aziridination of chiral electron-deficient olefins with N-chloro-N-sodiocarbamates catalyzed by chiral quaternary ammonium salts
Murakami, Yuta,Takeda, Youhei,Minakata, Satoshi
experimental part, p. 6277 - 6285 (2011/10/02)
Chiral quaternary ammonium salt-catalyzed diastereoselective aziridination of electron-deficient olefins that possess a chiral auxiliary with N-chloro-N-sodiocarbamates was developed. The key to high stereoselectivity was found to be the employment of the