25855-20-3

Basic information

• Product Name: Quinazoline, 2-phenyl-
• CAS NO: 25855-20-3
• Molecular Formula: C14H10N2
• Molecular Weight: 206.247
• Mol File: 25855-20-3.mol
• Article Data: 111

Chemical Properties

• CAS DataBase Reference: Quinazoline, 2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinazoline, 2-phenyl-(25855-20-3)
• EPA Substance Registry System: Quinazoline, 2-phenyl-(25855-20-3)

Safety Data

• Hazardous Substances Data: 25855-20-3(Hazardous Substances Data)

Upstream product

• 43120-25-8 1-benzyl-1H-indazole 
• 67-66-3 chloroform 
• 68521-38-0 benzocyclohepta<1,4>oxazine 
• 4403-69-4 2-amino-1-benzylamine 
• 6141-13-5 2-chloroquinazoline 
• 98-80-6 phenylboronic acid 
• 100-52-7 benzaldehyde 
• 529-23-7 o-aminobenzaldehyde 
• 46707-86-2 2-phenyl-4H-benzo[d][1,3]oxazine 
• 5344-90-1 2-Aminobenzyl alcohol 
• 3959-05-5 2-bromobenzylamine 
• 5333-86-8 ethyl benzimidate hydrochloride 
• 39959-51-8 2-iodobenzylamine 
• 1670-14-0 benzamidine monohydrochloride 

Downstream Products

• 1535484-59-3 N₁,N₃-bis(3,5-bis(trifluoromethyl)phenyl)-2-(quinazolin-2-yl)benzene-1,3-diamine 
• 1451360-22-7 C₂₃H₁₇⁽²⁾HN₂O 
• 1451359-33-3 (E)-4-(4-methoxystyryl)-2-phenylquinazoline 
• 1451359-25-3 (E)-2-phenyl-4-styrylquinazoline 
• 1451360-17-0 C₃₁H₃₃N₃O 
• 1451360-19-2 C₂₆H₂₄N₂O 
• 1022-45-3 2-phenyl-4(3H)-quinazolinone 
• 1451359-37-7 (E)-2-phenyl-4-(2-(thiophen-2-yl)vinyl)quinazoline 
• 1451359-35-5 (E)-4-(4-fluorostyryl)-2-phenylquinazoline 
• 1451359-31-1 (E)-4-(4-(tert-butyl)styryl)-2-phenylquinazoline 
• 1451359-29-7 (E)-4-(3-methylstyryl)-2-phenylquinazoline 
• 1451359-27-5 (E)-4-(4-methylstyryl)-2-phenylquinazoline 
• 1353000-45-9 2-phenylquinazoline-d 

Relevant articles and documents

2-Chloroquinazoline. Synthesis and reactivity of a versatile heterocyclic building block

Starting from 2,4-dichloroquinazoline, various methods for the selective removal of the 4-chloro substituent were tested, including catalytic hydrogenation, metal-halogen exchange, metal hydride reduction and reduction with tributyltin hydride-the latter

Method for catalyzing nitrogen heterocyclic ring aerobic dehydrogenation based on ionic liquid porous carbon material

The invention discloses a method for catalyzing nitrogen heterocycle aerobic dehydrogenation based on an ionic liquid porous carbon material, and is suitable for the field of organic synthesis. A heterogeneous catalysis system takes nitrogen heterocycle and derivatives thereof as substrates, a carbon material as a catalyst, water or ethanol as a solvent and air or oxygen spheres as an oxygen source, and a reaction is carried out at 0-80 DEG C under normal pressure, oxidative dehydrogenation of nitrogen heterocyclic compounds can be realized, and target products such as indole, quinoline, isoquinoline, quinazoline, quinoxaline, benzothiazole, Hanus ester and derivatives thereof and other medical intermediates can be synthesized. The non-metal catalyst is prepared by using the ionic liquid as the precursor, no activating agent or other additives are used in the reaction process, and the method has industrial application prospects.

Efficient access to quinolines and quinazolines by ruthenium complexes catalyzed acceptorless dehydrogenative coupling of 2-aminoarylmethanols with ketones and nitriles

Treatment of N,N,O-tridentate pyrazolyl-pyridinyl-alcohol ligands, 2-(CR1R2OH)-6-[3,5-(R3)2C3HN2]C5H3N (R1 = R2 = Me, R3 = H (L1H); R1 = Me, R2 = Ph, R3 = H (L2H); R1 = R2 = Ph, R3 = H (L3H); R1 = R2 = R3 = Me (L4H)) with RuCl3?xH2O in refluxing EtOH afforded the corresponding Ru(III) complexes L2RuCl (1a-1d), which were well characterized by IR, HR-MS and X-ray single crystal structural determination. These Ru complexes showed similarly high catalytic performance for both dehydrogenative couplings of 2-aminoarylmethanols with ketones and nitriles, giving the quinolines and quinazolines in good to excellent yields. This protocol provides an atom-economical and sustainable route to access various structurally important quinoline and quinazoline derivatives by using phosphine-free ligand based Ru catalysts.