257872-87-0

Basic information

• Product Name: 4-CHLORO-3-(TRIFLUOROMETHYL)CINNAMIC ACID
• Synonyms: 4-CHLORO-3-(TRIFLUOROMETHYL)CINNAMIC ACID;(E)-3-(4-CHLORO-3-TRIFLUOROMETHYL-PHENYL)-ACRYLIC ACID;RARECHEM BK HW 0183;3-(4-Chloro-3-(trifluoroMethyl)phenyl)acrylic acid
• CAS NO: 257872-87-0
• Molecular Formula: C₁₀H₆ClF₃O₂
• Molecular Weight: 250.6
• Product Categories: Cinnamic acid
• Mol File: 257872-87-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-CHLORO-3-(TRIFLUOROMETHYL)CINNAMIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-3-(TRIFLUOROMETHYL)CINNAMIC ACID(257872-87-0)
• EPA Substance Registry System: 4-CHLORO-3-(TRIFLUOROMETHYL)CINNAMIC ACID(257872-87-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 257872-87-0(Hazardous Substances Data)

Usage

General Description

4-CHLORO-3-(TRIFLUOROMETHYL)CINNAMIC ACID is a chemical compound with the molecular formula C10H6ClF3O2. It is an organic compound that consists of a benzene ring with a chloro, trifluoromethyl, and carboxylic acid group attached. 4-CHLORO-3-(TRIFLUOROMETHYL)CINNAMIC ACID is used in the pharmaceutical and chemical industries as an intermediate for the synthesis of various organic compounds. It has potential applications as a pharmaceutical ingredient due to its structural features and functional groups, making it a versatile building block for the synthesis of biologically active molecules. Additionally, it may also have applications in organic synthesis and material science due to its unique chemical properties and reactivity.

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 34328-46-6 4-chloro-3-(trifluoromethyl)benzaldehyde 
• 141-82-2 malonic acid 

Downstream Products

• 695187-18-9 methyl 3-(4-chloro-3-trifluoromethylphenyl)acrylate 
• 57661-53-7 3-(4-chloro-3-trifluoromethyl-phenyl)-N-(2,4-dioxo-imidazolidin-1-yl)-acrylamide 

Relevant articles and documents

Visible-light promoted oxidative cyclization of cinnamic acid derivatives using xanthone as the photocatalyst

We have developed an efficient photocatalytic synthesis of coumarin derivativesviaa tandem double bond isomerization/oxidative cyclization of cinnamic acids. Inexpensive and stable xanthone was used as the photocatalyst, and readily available Selectfluor was used as the oxidant. This method tolerates a wide range of functional groups and offers excellent chemical yields in general. Besides, the photocatalytic oxidative cyclization of cinnamic acid esters gives dimerized lignan-type products.

Synthesis and biological evaluation of N-(4-phenylthiazol-2-yl)cinnamamide derivatives as novel potential anti-tumor agents

In this study, a series of novel N-(4-phenylthiazol-2-yl)cinnamamide derivatives (7a-8n) were synthesized and evaluated for their anti-proliferative activities in vitro by MTT assay and a possible antitumor mechanism was also explored. SAR analysis showed that steric effects played an important role on the anti-tumor activity. The most potent analogue 8f showed excellent inhibitions on the K562, Bel7402, A549 and Jurkat cells ranging from sub-micromolar to nanomolar concentration. Compound 8f inhibited Jurkat cells with an IC50 value of 0.035 μM with no apparent toxicity in different non-cancerous cells. Furthermore, it was suggested that the possible mechanism of 8f might be associated with inducing cancer cell apoptosis following flow cytometer analysis and Hoechst 33358 staining assays.