255875-61-7

Basic information

• Product Name: 3,4,5-TRIFLUOROBENZOIC ACID
• Synonyms: BUTTPARK 30\01-46;RARECHEM AL BO 0682;3,4,5-Trifluorobenzoic acid radical ion
• CAS NO: 255875-61-7
• Molecular Formula: C7H3F3O2
• Molecular Weight: 176.09
• Mol File: 255875-61-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 97-99 °C(lit.)
• Boiling Point: 251.4 °C at 760 mmHg
• Flash Point: 105.9 °C
• Appearance: /
• Density: 1.536 g/cm³
• Water Solubility: at 25 deg C (mg/L): 442.2
• CAS DataBase Reference: 3,4,5-TRIFLUOROBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5-TRIFLUOROBENZOIC ACID(255875-61-7)
• EPA Substance Registry System: 3,4,5-TRIFLUOROBENZOIC ACID(255875-61-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 255875-61-7(Hazardous Substances Data)

Upstream product

• 773873-72-6 methyl 3,4,5-trifluorobenzoate 
• 132123-54-7 3,4,5-trifluorobenzaldehyde 
• 163733-96-8 3,4,5-trifluoro aniline 
• 530145-55-2 2,3,4-trifluoro-1,5-phenylenebis(triethylsilane) 
• 530145-56-3 (5-bromo-2,3,4-trifluorophenyl)triethylsilane 
• 176317-02-5 1-bromo-2,3,4-trifluorobenzene 
• 34628-01-8 1,2,3-tribromo-4,5,6-trifluoro-benzene 
• 17299-95-5 1,5-dibromo-2,3,4-trifluorobenzene 
• 17299-94-4 1,2-dibromo-3,4,5-trifluorobenzene 
• 1489-53-8 1,2,3-trifluorobenzene 
• 124-38-9 carbon dioxide 
• 138526-69-9 3,4,5-trifluoro-1-bromobenzene 
• 602-94-8 Pentafluorobenzoic acid 
• 456-22-4 4-Fluorobenzoic acid 

Downstream Products

• 173589-92-9 2-nitro-3,4,5-trifluorobenzoyl chloride 
• 495405-09-9 ethyl 3,4,5-trifluorobenzoate 
• 28177-48-2 2,6-difluorophenol 
• 226260-00-0 3,4,5-trifluoro-N-methoxy-N-methylbenzamide 
• 460752-10-7 tetra(p-tolyl)antimony 3,4,5-trifluorobenzoate 

Relevant articles and documents

Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus

A new class of diphenylurea was identified as a novel antibacterial scaffold with an antibacterial spectrum that includes highly resistant staphylococcal isolates, namely methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA & VRSA). Starting with a lead compound 3 that carries an aminoguanidine functionality from one side and a n-butyl moiety on the other ring, several analogues were prepared. Considering the pharmacokinetic parameters as a key factor in structural optimization, the structure-activity-relationships (SARs) at the lipophilic side chain were rigorously examined leading to the discovery of the cycloheptyloxyl analogue 21n as a potential drug-candidate. This compound has several notable advantages over vancomycin and linezolid including rapid killing kinetics against MRSA and the ability to target and reduce the burden of MRSA harboring inside immune cells (macrophages). Furthermore, the potent anti-MRSA activity of 21n was confirmed in?vivo using a Caenorhabditis elegans animal model. The present study provides a foundation for further development of diphenylurea compounds as potential therapeutic agents to address the burgeoning challenge of bacterial resistance to antibiotics.

PLANT DISEASE CONTROL AGENT, AND PLANT DISEASE CONTROL METHOD

Disclosed is a plant disease control agent comprising an amide compound represented by the formula (1) as an active ingredient. (1): wherein X1 represents a fluorine atom or a methoxy group; X2 represents a hydrogen atom, a halogen atom, a C1-C4 alkyl group, a C2-C4 alkenyl group, a C1-C4 haloalkyl group, a C1-C4 alkoxy group, a C1-C4 alkylthio group, a C1-C4 hydroxyalkyl group and so on; Z1 represents an oxygen atom or a sulfur atom; A1 represents a single bond, -CH2- and so on; and G1 represents a group CR6R7R8, a C3-6 cycloalkyl group and so on.

Regioselective ortho-hydrodefluorination of pentafluorobenzoic acid by low-valent nickel complexes

2,3,4,5-Tetrafluorobenzoic and 3,4,5-trifluorobenzoic acids were prepared in high yields by reaction of C6F5COOH with zinc in the presence of NiCl2-2′-bipyridine (or 1,10-phenanthroline) complexes.