252248-89-8

Basic information

• Product Name: 1-CinnaMoylpyrrole
• Synonyms: 1-CinnaMoylpyrrole;(2E)-3-Phenyl-1-(1H-pyrrol-1-yl)-2-propen-1-one
• CAS NO: 252248-89-8
• Molecular Formula: C₁₃H₁₁NO
• Molecular Weight: 197.23254
• Mol File: 252248-89-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 101-105℃
• Appearance: /
• CAS DataBase Reference: 1-CinnaMoylpyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CinnaMoylpyrrole(252248-89-8)
• EPA Substance Registry System: 1-CinnaMoylpyrrole(252248-89-8)

Safety Data

• Hazardous Substances Data: 252248-89-8(Hazardous Substances Data)

Usage

General Description

1-Cinnamoylpyrrole is a chemical compound consisting of a pyrrole ring with a cinnamoyl functional group attached. It is commonly used as a precursor in the synthesis of various organic compounds and has shown potential as a building block for the development of new materials and pharmaceuticals. The presence of the cinnamoyl group lends specific properties to the molecule, making it useful for applications in organic chemistry and material science. Research into the potential uses and properties of 1-Cinnamoylpyrrole is ongoing, and it continues to be of interest to chemists and researchers in various fields.

Upstream product

• 864953-57-1 diethyl 2-oxo-2-(pyrrol-1-yl)ethylphosphonate 
• 100-52-7 benzaldehyde 
• 109-97-7 pyrrole 
• 102-92-1 Cinnamoyl chloride 
• 627546-31-0 1-(1H-pyrrol-1-yl)-2-(triphenylphosphoranylidene)ethanone 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 621-79-4 cinnamamide 
• 54582-33-1 1,1'-carbonyldiimidazole 
• 1370360-36-3 N-(2,4,4-trimethoxybutyl)cinnamamide 

Downstream Products

• 836598-15-3 (3S)-3-cyano-3-phenyl-1-pyrrol-1-ylpropan-1-one 
• 864953-64-0 (S)-3-methoxyamino-3-phenyl-1-pyrrol-1-yl-propan-1-one 
• 1021867-79-7 4-nitro-3-phenyl-1-pyrrol-1-yl-butan-1-one 
• 1071992-26-1 3-phenyl-1-pyrrol-1-yl-5-hexene-1-one 
• 1360768-91-7 (2S,3S)-1'-methyl-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione 
• 1374418-71-9 (2R,3R)-1'-methyl-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione 
• 1608108-55-9 ((1S,2S,3R)-3-(cyclopropylethynyl)-4-methylene-2-phenylcyclopentyl)(1H-pyrrol-1-yl)methanone 
• 1608108-54-8 ((1S,2S,3R)-3-(3,3-diethoxyprop-1-yn-1-yl)-4-methylene-2-phenylcyclopentyl)(1H-pyrrol-1-yl)-methanone 
• 1608108-53-7 ((1S,2S,3R)-3-(3-((tert-butyldimethylsilyl)oxy)prop-1-yn-1-yl)-4-methylene-2-phenylcyclopentyl)(1H-pyrrol-1-yl)methanone 
• 1608108-51-5 ((1S,2S,3R)-4-methylene-2-phenyl-3-((trimethylsilyl)ethynyl)cyclopentyl)(1H-pyrrol-1-yl)methanone 

Relevant articles and documents

α,β-Unsaturated N-Acylindoles: An Alternative Class of Michael Acceptors and Their Application in Asymmetric Borylation

Copper(I)-catalyzed enantioselective borylation of α,β-unsaturated N-acylindoles as well as N-acylpyrroles was efficiently achieved by means of bis(pinacolato)diboron (B2pin2), affording the enantioenriched products in excellent yields with up to 99% ee. The present work provides an alternative class of Michael acceptors, that is, α,β-unsaturated N-acylindoles, for potential asymmetric transformations.

A practical preparation of highly versatile N-acylpyrroles from 2,4,4-trimethoxybutan-1-amine

A novel method for the preparation of N-acylpyrrole is described. The method involves condensation of carboxylic acids with 2,4,4-trimethoxybutan-1- amine, followed by acid-mediated cyclization to form the pyrrole ring. The preparative procedure is highly

Catalytic asymmetric epoxidation of α,β-unsaturated N-acylpyrroles as monodentate and activated ester equivalent acceptors

Catalytic asymmetric epoxidation of α,β-unsaturated N-acylpyrroles as monodentate and activated ester equivalent acceptors is described. A Sm(O-i-Pr)3/(R)-H8-BINOL complex promoted the epoxidation reaction to afford products in high yield (up to quant) and high enantiomeric excess (up to >99.5% ee). Reaction proceeded smoothly using cumene hydroperoxide (CMHP) with low explosive hazard, and completed within 0.2-0.5 h with 5 mol % catalyst. Catalyst loading was successfully reduced to as little as 0.02 mol %. The N-acylpyrrole properties as well as efficient synthesis of α,β-unsaturated N-acylpyrroles are also described.