2453-48-7 Usage
Description
Hexanenitrile,6-hydroxy-, also known as 6-Hydroxyhexanenitrile, is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by the presence of a hydroxyl group and a nitrile group in its molecular structure, which contribute to its reactivity and potential applications in the chemical and pharmaceutical industries.
Uses
Used in Pharmaceutical Synthesis:
Hexanenitrile,6-hydroxyis used as an intermediate in the synthesis of 6-?Chlorohexanenitrile (C350330), which is a vital reagent in the production of dual histamine H1 and H2 receptor antagonists. These antagonists are essential in the treatment of various allergic reactions and other conditions related to histamine release.
Used in Anticancer Applications:
In the field of oncology, Hexanenitrile,6-hydroxyis utilized in the preparation of dual action MDR anthranilamide modulators with activity against CYP450. These modulators play a significant role in tumor treatment by overcoming multidrug resistance (MDR) in cancer cells, thus enhancing the effectiveness of chemotherapy.
Used in Chemical Synthesis:
Hexanenitrile,6-hydroxyis also employed in the chemical industry as a building block for the synthesis of various other organic compounds. Its unique functional groups make it a versatile starting material for the development of new molecules with potential applications in different industries, including pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 2453-48-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,5 and 3 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2453-48:
(6*2)+(5*4)+(4*5)+(3*3)+(2*4)+(1*8)=77
77 % 10 = 7
So 2453-48-7 is a valid CAS Registry Number.
2453-48-7Relevant articles and documents
Oxidative conversion of amines into their corresponding nitriles using o-iodoxybenzoic acid (IBX)/iodine: Selective oxidation of aminoalcohols to hydroxynitriles
Chiampanichayakul, Supanimit,Pohmakotr, Manat,Reutrakul, Vichai,Jaipetch, Thaworn,Kuhakarn, Chutima
body text, p. 2045 - 2048 (2009/04/11)
o-Iodoxybenzoic acid (IBX)/iodine in dimethyl sulfoxide at 65 °C oxidatively and efficiently converted various amines into the corresponding nitriles in good to excellent yields. Under the reaction conditions, amines were selectively oxidized to the nitrile in the presence of a primary hydroxy group within the same molecule. Thieme Stuttgart.
