245116-08-9Relevant articles and documents
Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis
Lu, Tianbao,Markotan, Thomas,Coppo, Frank,Tomczuk, Bruce,Crysler, Carl,Eisennagel, Stephen,Spurlino, John,Gremminger, Lisa,Soll, Richard M.,Giardino, Edward C.,Bone, Roger
, p. 3727 - 3731 (2007/10/03)
Through structure-based drug design and parallel synthesis, we have discovered a novel series of nonpeptidic phenyl-based thrombin inhibitors using oxyguanidines as guanidine bioisosteres. These compounds have been found to be highly potent, highly selective, and orally bioavailable.
