243666-35-5

Basic information

• Product Name: (R)-6-methyl-4-(4-chlorophenyl)chroman-2-one
• Synonyms: (R)-6-methyl-4-(4-chlorophenyl)chroman-2-one
• CAS NO: 243666-35-5
• Molecular Weight: 272.731
• Mol File: 243666-35-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-6-methyl-4-(4-chlorophenyl)chroman-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-6-methyl-4-(4-chlorophenyl)chroman-2-one(243666-35-5)
• EPA Substance Registry System: (R)-6-methyl-4-(4-chlorophenyl)chroman-2-one(243666-35-5)

Safety Data

• Hazardous Substances Data: 243666-35-5(Hazardous Substances Data)

Upstream product

• 1679-18-1 4-Chlorophenylboronic acid 
• 92-48-8 6-methylcoumarin 

Relevant articles and documents

Palladium Catalyzed Enantioselective Hayashi-Miyaura Reaction for Pharmaceutically Important 4-Aryl-3,4-dihydrocoumarins

The first palladium-catalyzed asymmetric addition of arylboronic acids to coumarins was successfully established, providing a straightforward asymmetric approach to achieving pharmaceutically important 4-aryl-3,4-dihydrocoumarins. This methodology features easily accessible and bench-stable ligands, a wide substrate scope, mild conditions, and accommodation of electron-withdrawing arylboronic acids.

Rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to coumarins: Asymmetric synthesis of (R)-tolterodine

(Chemical Equation Presented) Rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to coumarins proceeded with high enantioselectivity in the presence of a rhodium catalyst (3 mol %) generated from Rh(acac)(C 2H4)2 and (R)-Segphos to give the corresponding (R)-4-arylchroman-2-ones in over 99% ee. This asymmetric reaction was applied to the synthesis of (R)-tolterodine.