24279-91-2

Basic information

• Product Name: carboquone
• Synonyms: carboquone;Carbazilquinone;Esquinon;Carbazylquinone;2,5-Cyclohexadiene-1,4-dione, 2-[2-[(aminocarbonyl)oxy]-1-methoxyethyl]-3,6-bis(1-aziridinyl)-5-methyl-;Esquinone;NSC 134679;p-Benzoquinone, 2,5-bis(1-aziridinyl)-3-(2-hydroxy-1-methoxyethyl)-6-methyl-, carbamate (ester) (8CI)
• CAS NO: 24279-91-2
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.15062
• Mol File: 24279-91-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 202° (dec)
• Boiling Point: 460.09°C (rough estimate)
• Flash Point: 275.7°C
• Appearance: /
• Density: 1.1990 (rough estimate)
• Vapor Pressure: 2.07E-11mmHg at 25°C
• Refractive Index: 1.5600 (estimate)
• PKA: 13.14±0.50(Predicted)
• CAS DataBase Reference: carboquone(CAS DataBase Reference)
• NIST Chemistry Reference: carboquone(24279-91-2)
• EPA Substance Registry System: carboquone(24279-91-2)

Safety Data

• Hazardous Substances Data: 24279-91-2(Hazardous Substances Data)

Usage

Originator

Esquinon,Sankyo,Japan,1974

Manufacturing Process

In 10 ml of ethanol was dissolved with heating 200 mg of 2-methyl-5-(1- methoxy-2-carbamoyloxyethyl)-1,4-benzoquinone and the resulting solution was cooled. To the cooled solution was added 0.5 ml of aziridine and then the resulting mixture was allowed to stand in a refrigerator at 5°C to 8°C for 4 days. Thereafter, the crystalline substance which precipitated in situ was recovered by filtration and washed with ethanol to give 50 mg of the desired product as red crystals melting at 200°C (with decomposition).

Therapeutic Function

Antineoplastic

Safety Profile

A poison via ingestion,intraperitoneal, subcutaneous, and intravenous routes.Mutation data reported. When heated to decomposition itemits toxic NOx.

InChI:InChI=1/C15H19N3O5/c1-8-11(17-3-4-17)14(20)10(9(22-2)7-23-15(16)21)12(13(8)19)18-5-6-18/h9H,3-7H2,1-2H3,(H2,16,21)

Downstream Products

• 103429-77-2 3-(2-carbamoyloxy-1-methoxyethyl)-2,5-dimethoxy-6-methyl-1,4-benzoquinone 
• 103429-76-1 3-(2carbamoyloxy-1-methoxyethyl)-2-methoxy-5-(2-methoxyethyl)amino-6-methyl-1,4-benzoquinone 
• 103429-75-0 2-(1-aziridinyl)-3-(carbamoyloxy-1-methoxyethyl)-5-methoxyetylamino-6-methyl-1,4-benzoquinone 
• 103429-80-7 3-(2-carbamoyloxy-1-methoxyethyl)-5-methoxy-2-(2-methoxyethyl)amino-6-methyl-1,4-benzoquinone 
• 103445-49-4 1-(1-aziridinyl)-3-(2-carbamoyloxy-1-methoxyethyl)-5-methoxy-6-methyl-1,4-benzoquinone 
• 103429-74-9 5-(1-aziridinyl)-3-(2-carbamoyloxy-1-methoxyethyl)-2-methoxy-6-methyl-1-4-benzoquinone 
• 103429-78-3 5-(1-aridinyl)-2-methoxyethylamino-3-(2-carbamoyloxy-1-methoxyethyl)-5-methyl-1,4-benzoquinone 
• 92812-36-7 Carbamic acid 2-[2-aziridin-1-yl-5-(2-hydroxy-ethylamino)-4-methyl-3,6-dioxo-cyclohexa-1,4-dienyl]-2-methoxy-ethyl ester 
• 92778-35-3 Carbamic acid 2-[5-aziridin-1-yl-2-(2-hydroxy-ethylamino)-4-methyl-3,6-dioxo-cyclohexa-1,4-dienyl]-2-methoxy-ethyl ester 
• 92778-36-4 Carbamic acid 2-[2,5-bis-(2-hydroxy-ethylamino)-4-methyl-3,6-dioxo-cyclohexa-1,4-dienyl]-2-methoxy-ethyl ester 
• 92778-40-0 Carbamic acid 2-[5-hydroxy-2-(2-hydroxy-ethylamino)-4-methyl-3,6-dioxo-cyclohexa-1,4-dienyl]-2-methoxy-ethyl ester 
• 92778-41-1 Carbamic acid 2-[2-hydroxy-5-(2-hydroxy-ethylamino)-4-methyl-3,6-dioxo-cyclohexa-1,4-dienyl]-2-methoxy-ethyl ester 
• 92778-37-5 2,5-dihydroxy-3-(2-carbamoyloxy-1-methoxyethyl)-6-methyl-1,4-benzoquinone 
• 92778-38-6 Carbamic acid 2-(5-aziridin-1-yl-2-hydroxy-4-methyl-3,6-dioxo-cyclohexa-1,4-dienyl)-2-methoxy-ethyl ester 

Relevant articles and documents

Particles with improved solubilization capacity

A particle is disclosed that comprises a first volume of hydrophobe-rich material with tunable dissolution and solubilization characteristics and a distinct second volume of nanostructured nonlamellar liquid crystalline material, said second volume containing said first domain and being capable of being in equilibrium with said first volume. Preferably, the nanostructured nonlamellar liquid crystalline material is capable of being in equilibrium with a polar solvent or a water-immiscible solvent or both.