24240-04-8

Basic information

• Product Name: ALLOCRYPTOPINE
• Synonyms: ALPHA-ALLOCRYPTOPINE;ALLOCRYPTOPINE, ALPHA-;ALLOCRYPTOPINE;3,4-DIMETHOXY-6-METHYL-5,7,8,15-TETRAHYDRO-6H-BENZO[C][1,3]DIOXOLO[4',5':4,5]BENZO[1,2-G]AZECIN-14-ONE;.beta.-Allocryptopine;.gamma.-Homochelidonine;Benzo[E][1,3]dioxolo[4,5-K][3]benzazecin-14(6H)-one, 5,7,8,15-tetrahydro-3,4-dimethoxy-6-methyl-;Fagarine i
• CAS NO: 24240-04-8
• Molecular Formula: C21H23NO5
• Molecular Weight: 369.41
• Mol File: 24240-04-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 169-170 °C
• Boiling Point: 552.7 °C at 760 mmHg
• Flash Point: 288.1 °C
• Appearance: /
• Density: 1.216g/cm³
• PKA: 7.86±0.20(Predicted)
• CAS DataBase Reference: ALLOCRYPTOPINE(CAS DataBase Reference)
• NIST Chemistry Reference: ALLOCRYPTOPINE(24240-04-8)
• EPA Substance Registry System: ALLOCRYPTOPINE(24240-04-8)

Safety Data

• Hazardous Substances Data: 24240-04-8(Hazardous Substances Data)

Usage

General Description

Allocryptopine is a natural benzylisoquinoline alkaloid found in several plant species, including the Nelumbo nucifera (lotus) and Cocculus laurifolius (laurel-leaved snailseed). It has been studied for its potential pharmacological properties, including anti-inflammatory, anti-cancer, and neuroprotective effects. Allocryptopine has also shown potential as an antioxidant and has been investigated for its possible role in preventing cardiovascular diseases. Additionally, it has been reported to exhibit anti-diabetic properties and may have potential as a therapeutic agent for managing diabetes. Overall, research on allocryptopine suggests that it may have diverse pharmacological activities, making it a promising compound for further exploration and potential development of therapeutic applications.

Upstream product

• 41759-45-9 (Z)-3,4-dimethoxy-6-methyl-5,6,7,8-tetrahydro-benzo[c][1,3]dioxolo[4',5':4,5]benzo[1,2-g]azecine 
• 41759-43-7 9,10-dimethoxy-7-methyl-5,8,12b,13-tetrahydro-6H-[1,3]dioxolo[4'',5'':4,5]benzo[1',2':4,5]azepino[2,1-a]isoindolium; bromide 
• 3906-36-3 9,10-dimethoxy-5,6,7,8,13,13a-hexahydro-2H-1,3-dioxolano[4,5-g]isoquinolino[3,2-a]isoquinoline-N-oxide 
• 112333-20-7 14-hydroxy-3,4-dimethoxy-5,6,7,8,14,15-hexahydrobenzo<1,3>dioxolo<4,5-k><3>benzazecine-6-carbonitrile 
• 112333-56-9 (+/-)-14-Dihydro-nor-muramin 
• 18441-14-0 (+/-)-cis-N-methyl-7,8,13,13a-tetrahydroberberinium iodide 
• 633-65-8 berberine chloride 
• 29074-38-2 canadine 
• 41759-47-1 3,4-dimethoxy-6-methyl-5,6,7,8-tetrahydro-11H-benzo[c][1,3]benzodioxolo[5,6-g]azecine 
• 18441-14-0 (+/-)-trans-N-methyl-7,8,13,13a-tetrahydroberberinium iodide 
• 61774-67-2 (-)-N-methylcanadine iodide 
• 883867-23-0 14-boranyl-3,4-dimethoxy-6-methyl-5,6,7,8,14,15-hexahydro-benzo[c][1,3]dioxolo[4',5':4,5]benzo[1,2-g]azecine 
• 16211-68-0 (+/-)-cis-N-methyl-7,8,13,13a-tetrahydroberberinium chloride 
• 14358-63-5 dihydroallocryptopine 

Downstream Products

• 2086-83-1 berberine 

Relevant articles and documents

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From berbines to protopines: Regiocontrolled Hofmann elimination/ hydroboration/oxidation of N-substituted berbinium salts

An improved synthetic approach to protopines based on the sequential Hofmann elimination, hydroboration and oxidation of N-(arylmethyl)berbinium salts has been designed. By using berberine chloride as the starting material, this sequence of reactions has provided two new nonnatural protopines, N-benzyl-N-nordihydroallocriptopine and N-(p-methoxybenzyl)-N- nordihydroallocriptopine and the natural allocriptopine. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

ENZYMATIC FORMATION OF PROTOPINES BY A MICROSOMAL CYTOCHROME P-450 SYSTEM OF CORYDALIS VAGINANS

A microsomal cytochrome P-450-NADPH dependent enzyme which hydroxylates stereo- and regiospecifically carbon atom 14 of (S)-cis-N-methyltetrahydroprotoberberines has been discovered in a number of plant cell cultures originating from species containing protopine alkaloids; the monooxygenase was solubilized, partially purified (100-fold) and characterized.