2415-85-2

Basic information

• Product Name: N-(4-Methylphenyl)-3-oxobutanamide
• Synonyms: N-ACETOACETYL-P-TOLUIDINE;N-(4-METHYLPHENYL)-3-OXOBUTANAMIDE;Acetoacet-para-toluidine;n-(4-methylphenyl)-3-oxo-butanamid;AURORA KA-3343;4'-METHYLACETOACETANILIDE;AKOS B029143;ACETOACET-P-TOLUIDIDE
• CAS NO: 2415-85-2
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• EINECS: 219-327-7
• Product Categories: Intermediates of Dyes and Pigments;Aromatic amine products
• Mol File: 2415-85-2.mol
• Article Data: 36

Chemical Properties

• Melting Point: 95°C
• Boiling Point: 376 °C at 760 mmHg
• Flash Point: 162 °C
• Appearance: Off-white crystalline powder flakes
• Density: 1.132 g/cm³
• Vapor Pressure: 7.5E-06mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.32±0.46(Predicted)
• CAS DataBase Reference: N-(4-Methylphenyl)-3-oxobutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Methylphenyl)-3-oxobutanamide(2415-85-2)
• EPA Substance Registry System: N-(4-Methylphenyl)-3-oxobutanamide(2415-85-2)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 2811
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 2415-85-2(Hazardous Substances Data)

Usage

Chemical Properties

Grey white flake crystalline powder

InChI:InChI=1/C11H13NO2/c1-8-3-5-10(6-4-8)12-11(14)7-9(2)13/h3-6H,7H2,1-2H3,(H,12,14)

Upstream product

• 1118-84-9 allyl acetoacetate 
• 106-49-0 p-toluidine 
• 542-08-5 isopropyl acetoacetate 
• 105-45-3 acetoacetic acid methyl ester 
• 5396-89-4 benzyl acetoacetate 
• 31009-91-3 2-chloro-3-oxo-N-(ptolyl)butanamide 
• 1694-31-1 tert-butyl acetoacetate 
• 85322-34-5 (Z)-5-(p-methylphenylcarbamoyl)-methylene-3-phenyl-5,6-dihydro-4H-1,2,4-oxadiazine 
• 103677-62-9 N-(1-p-tolylcarbamoyl-2-propylidene)benzamide oxime 
• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 
• 141-97-9 ethyl acetoacetate 
• 674-82-8 4-methyleneoxetan-2-one 

Downstream Products

• 23947-37-7 4,6-dimethylquinolin-2(1H)-one 
• 1477491-90-9 2,2-dichloro-3-oxo-N-(p-tolyl)butanamide 
• 1235891-27-6 C₂₃H₂₁N₃O₂ 
• 1235891-35-6 C₂₂H₁₉N₃O₂ 
• 866846-52-8 5-methyl-1-phenyl-N-(p-tolyl)-1H-1,2,3-triazole-4-carboxamide 
• 13664-07-8 3-anilino-3-thioxo-N-4-tolylpropanamide 
• 1149748-07-1 3-(benzylamino)-3-thioxo-N-4-tolylpropanamide 
• 1182301-68-3 C₂₂H₂₂N₂O₂ 
• 1189178-07-1 1-(3-chloro-4-fluorophenyl)-6-methyl-N-(4-methylphenyl)-4-(2-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one-5-carboxamide 
• 1189178-06-0 1-(3-chloro-4-fluorophenyl)-6-methyl-N-(4-methylphenyl)-4-(3-chlorophenyl)-3,4-dihydropyrimidin-2(1H)-one-5-carboxamide 
• 1189178-11-7 1-(3-chloro-4-fluorophenyl)-6-methyl-N-(4-methylphenyl)-4-(3,4-dimethoxyphenyl)-3,4-dihydropyrimidin-2(1H)-one-5-carboxamide 
• 1189178-10-6 1-(3-chloro-4-fluorophenyl)-6-methyl-N-(4-methylphenyl)-4-(4-methoxyphenyl)-3,4-dihydropyrimidin-2(1H)-one-5-carboxamide 
• 1189178-12-8 1-(3-chloro-4-fluorophenyl)-6-methyl-N-(4-methylphenyl)-4-(4-hydroxyphenyl)-3,4-dihydropyrimidin-2(1H)-one-5-carboxamide 
• 1189178-08-2 1-(3-chloro-4-fluorophenyl)-6-methyl-N-(4-methylphenyl)-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one-5-carboxamide 

Relevant articles and documents

Ru-NHC-Catalyzed Asymmetric Hydrogenation of 2-Quinolones to Chiral 3,4-Dihydro-2-Quinolones

Direct enantioselective hydrogenation of unsaturated compounds to generate chiral three-dimensional motifs is one of the most straightforward and important approaches in synthetic chemistry. We realized the Ru(II)-NHC-catalyzed asymmetric hydrogenation of 2-quinolones under mild reaction conditions. Alkyl-, aryl- and halogen-substituted optically active dihydro-2-quinolones were obtained in high yields with moderate to excellent enantioselectivities. The reaction provides an efficient and atom-economic pathway to construct simple chiral 3,4-dihydro-2-quinolones. The desired products could be further reduced to tetrahydroquinolines and octahydroquinolones.

Synthesis and anticonvulsant activity of some 1,4-dihydropyridine derivatives

A series of asymmetrical 4-alkyl/aryl-2,6-dimethyl-3-N-(aryl/heteroaryl)-carbamoyl-5-ethoxycarbonyl-1, 4-dihydropyridines 3a-d and symmetrical 4-alkyl/aryl-2,6-dimethyl-3,5-bis-(ethoxycarbonyl)-1,4-dihydropyridines 4a and 4b have been prepared by the condensation of various benzaldehydes, ethylacetoacetate, 2-aminopyridine or p-toludine in ethanol (Hantzch method). The structures of all the synthesized 1,4-dihydropyridine derivatives have been confirmed by spectral data (IR,1H NMR) and elemental analysis. Compounds 3a-c, 4a and 4b (10 mg/kg) have been evaluated for their anticonvulsant effect against pentylenetetrazole- induced convulsions with phenytoin (4 mg/kg) as the standard. The anticonvulsant potential of the newly synthesized compounds have been assessed on the basis of increase in latency (onset time) to induce convulsions; decrease in number of convulsions and increase in latency of death compared to control and standard.

2- Amino -3,4-dihydropyran -3- formamide analogue as well as preparation method and application thereof

The invention relates to a preparation method 2 - of a compound containing, amino - 333384-dihydropyran - 3 3, which comprises the following step :1) of linking diketene with R. 2 NH2 The reaction is stirred in a solvent to complete. ;2) Is added R. 3 NH2 , R1 CHO And a of Compound, and adding elemental iodine to reaction solution to complete curing, and drying the filter cake to obtain compound 2 - containing. amino - 3333,4-dihydropyran - 3 3-carboxamide compound, according to the present invention as well as its use. without isolation of intermediate, in a simple.