23786-13-2

Basic information

• Product Name: METHYL 4-METHYLPHENYLACETATE
• Synonyms: P-TOLYLACETIC ACID METHYL ESTER;P-METHYLPHENYLACETIC ACID METHYL ESTER;ASISCHEM D13370;METHYL P-TOLYLACETATE;METHYL 4-METHYLPHENYLACETATE;4-METHYLPHENYLACETIC ACID METHYL ESTER;P-methylphenylmethyl acetate;2-(4-Methylphenyl)acetic acid methyl ester
• CAS NO: 23786-13-2
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2
• EINECS: 245-885-6
• Mol File: 23786-13-2.mol
• Article Data: 65

Chemical Properties

• Melting Point: 60-60.5 °C
• Boiling Point: 118 °C (13 mmHg)
• Flash Point: 100.2 °C
• Appearance: clear light yellow liquid
• Density: 1.04
• Vapor Pressure: 0.0773mmHg at 25°C
• Refractive Index: 1.5035-1.5055
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL 4-METHYLPHENYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-METHYLPHENYLACETATE(23786-13-2)
• EPA Substance Registry System: METHYL 4-METHYLPHENYLACETATE(23786-13-2)

Safety Data

• Safety Statements: 24/25
• RIDADR: 1993
• WGK Germany: 3
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 23786-13-2(Hazardous Substances Data)

Usage

Chemical Properties

clear light yellow liquid

Synthesis Reference(s)

Journal of the American Chemical Society, 93, p. 4919, 1971 DOI: 10.1021/ja00748a051The Journal of Organic Chemistry, 50, p. 149, 1985 DOI: 10.1021/jo00201a038

InChI:InChI=1/C10H12O2/c1-8-3-5-9(6-4-8)7-10(11)12-2/h3-6H,7H2,1-2H3

Upstream product

• 67-56-1 methanol 
• 2947-61-7 (4-methylphenyl)acetonitrile 
• 122-00-9 para-methylacetophenone 
• 149-73-5 trimethyl orthoformate 
• 35675-44-6 4-methylphenylacetyl chloride 
• 33155-60-1 t-butyl p-tolylacetate 
• 622-79-7 benzyl azide 
• 766-97-2 4-n-methylphenylacetylene 
• 622-47-9 4-tolylacetic acid 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 7664-93-9 sulfuric acid 
• 7757-82-6 sodium sulfate 
• 101752-05-0 methanol hydrochloride 
• 201230-82-2 carbon monoxide 

Downstream Products

• 34966-53-5 methyl 4-methylphenylglyoxylate 
• 77053-52-2 methyl bromo(4-methylphenyl)acetate 
• 622-47-9 4-tolylacetic acid 
• 57676-54-7 4-Methyl-phenylessigsaeurehydrazid 
• 100074-53-1 3-(4-methylphenyl)-4-hydroxyfuran-2(5H)-one 
• 66616-85-1 α-(4-methylphenyl)acrylic acid 
• 143918-73-4 3-Oxo-2-p-tolyl-butyric acid methyl ester 
• 68682-48-4 methyl 2-methyl-2-(4-methylphenyl)propanoate 

Relevant articles and documents

Green Esterification of Carboxylic Acids Promoted by tert-Butyl Nitrite

In this work, the green esterification of carboxylic acids promoted by tert-butyl nitrite has been well developed. This transformation is compatible with a broad range of substrates and exhibits excellent functional group tolerance. Various drugs and substituted amino acids are applicable to this reaction under near neutral conditions, with good to excellent yields.

Preparation method of 4-bromomethyl methyl benzoate and derivative thereof

The invention provides a preparation method of methyl 4-bromomethyl benzoate and a derivative thereof, and the method comprises an esterification reaction for converting methyl benzoic acid into methyl benzoate and a bromination reaction for converting the methyl benzoate into the methyl 4-bromomethyl benzoate and the derivative thereof, the brominating agent for the bromination reaction is dibromohydantoin, and the structural formulas of the 4-bromomethyl methyl benzoate and the derivatives thereof are shown in the specification, wherein n1 is equal to 0, 1 or 2; n2 is equal to 1 or 2; according to the preparation method disclosed by the invention, the reaction time can be greatly shortened, the reaction yield is high, and the production efficiency is improved.

B(C6F5)3-Catalyzed site-selective N1-alkylation of benzotriazoles with diazoalkanes

Alkylation of benzotriazoles is synthetically challenging, often leading to mixtures of N1 and N2 alkylation. Herein, metal-free catalytic site-selective N1-alkylation of benzotriazoles with diazoalkanes is described in the presence of 10 mol% of B(C6F5)3. These reactions provide N1-alkylated benzotriazoles in good to excellent yields and this protocol is successfully adapted to gram-scale syntheses as well as a derivative with antimicrobial activity.