23583-48-4 Usage
Description
8-BROMOADENOSINE 3':5'-CYCLIC MONOPHOSPHATE, also known as 8-Bromo-cAMP, is a 3',5'-cyclic purine nucleotide that features an additional bromo substituent at position 8 on the adenine ring. It is a membrane-permeable analog of cyclic AMP (cAMP) and serves as an activator of cyclic AMP-dependent protein kinase. This white powder is a significant molecule in cellular signaling and has been explored for its potential applications in various fields.
Uses
Used in Pharmaceutical Research:
8-BROMOADENOSINE 3':5'-CYCLIC MONOPHOSPHATE is used as a research tool for studying the effects of cAMP on cellular processes. It is particularly useful in investigating the role of cAMP in signal transduction pathways and its influence on gene expression.
Used in Cell Culture Studies:
In the field of cell culture, 8-BROMOADENOSINE 3':5'-CYCLIC MONOPHOSPHATE is used as a positive control for CYP19 induction in H295R cells. This application aids researchers in understanding the mechanisms underlying the regulation of gene expression and the role of cAMP in cellular processes.
Used in Electrophysiology:
8-BROMOADENOSINE 3':5'-CYCLIC MONOPHOSPHATE is used as a membrane-permeable cAMP analog to study its effect on short-circuit current (Isc). This application is valuable in understanding the impact of cAMP on ion transport and membrane potential in various cell types.
Used in Stem Cell Research:
In the field of stem cell research, 8-BROMOADENOSINE 3':5'-CYCLIC MONOPHOSPHATE is used to investigate its potential as an inducer of differentiation in Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs). This application is crucial in exploring the molecular mechanisms that govern stem cell differentiation and the role of cAMP in this process.
Used in the Pharmaceutical Industry:
8-BROMOADENOSINE 3':5'-CYCLIC MONOPHOSPHATE is used as an active ingredient in the development of drugs targeting cyclic AMP-dependent protein kinase. Its role in modulating cellular signaling pathways makes it a promising candidate for therapeutic applications in various diseases.
Used in the Biotechnology Industry:
In the biotechnology industry, 8-BROMOADENOSINE 3':5'-CYCLIC MONOPHOSPHATE is used as a key component in the development of novel drug delivery systems and gene therapy approaches. Its ability to modulate cellular processes and influence gene expression makes it a valuable tool in the design of targeted therapies and personalized medicine.
Biochem/physiol Actions
8-bromo-adenosine?3′,5′-cyclic?monophosphate?(8-bromo-cAMP), added to hepatocytes during plating helps to increase the acquisition of beta-adrenoceptors.
Check Digit Verification of cas no
The CAS Registry Mumber 23583-48-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,5,8 and 3 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 23583-48:
(7*2)+(6*3)+(5*5)+(4*8)+(3*3)+(2*4)+(1*8)=114
114 % 10 = 4
So 23583-48-4 is a valid CAS Registry Number.
23583-48-4Relevant articles and documents
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Chu et al.
, p. 406 (1974)
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PROCESS FOR THE PREPARATION OF AN (RP)-8-SUBSTITUTED CAMPS
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Page/Page column 8-9; 12, (2008/06/13)
This invention relates to a process for the preparation of an (Rp)-8-substituted adenosine-3',5'-cyclic phosphorothioic acid, or a salt or ester thereof, which comprises P-amidating 8-bromoadenosine-3',5'-cyclic phosphoric acid, and reacting the P-amidate with a base and with carbon disulphide to yield (Rp)-8-bromoadenosine-3',5'-cyclic phosphorothioic acid or a salt or ester thereof.
PURINE NUCLEOTIDE DERIVATIVES
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Page/Page column 64, (2010/02/15)
This invention provides novel 8-carbyl substituted cAMPS and a novel procedures for the preparation of 8-Br-cAMP, a key starting material.
Chemical synthesis and biological activity of 8-substituted adenosine 3',5'-cyclic monophosphate derivatives.
Muneyama et al.
, p. 2390,2391,2392 (2007/10/10)
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